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NFKBIA — WDR61
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Tsuyuki et al., Biochim Biophys Acta 2002
:
In a culture of rat peritoneal macrophages, exogenously added
PAF did not
induce degradation of
IkappaB-alpha
Hidalgo et al., Br J Pharmacol 2005
:
However, andrographolide did not reduce phosphorylation of p38 MAPK or ERK1/2 and did not change
IkappaB alpha degradation
induced by
PAF and fMLP
Borthakur et al., Inflamm Bowel Dis 2010
:
Bcl10 was required for
PAF induced
I kappaB alpha phosphorylation, NF-kappaB activation, and IL-8 production in NCM460, a cell line derived from normal human colon, and Caco-2, a transformed human intestinal cell line
Kravchenko et al., J Biol Chem 1995
:
PAF induced an initial decrease and subsequent increase of cytoplasmic
I kappa B alpha levels, accompanied by up-regulation of the I kappa B alpha messenger RNA, a feature of NF-kappa B activation