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PTK7 — WNT16

Text-mined interactions from Literome

Peradziryi et al., EMBO J 2011 : PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling ... PTK7/Otk co-precipitates canonical Wnt3a and Wnt8 , indicating a role in Wnt signalling, but PTK7 inhibits rather than activates canonical Wnt activity in Xenopus, Drosophila and luciferase reporter assays
Hayes et al., Development 2013 (Wnt Signaling Pathway) : However, conflicting reports have indicated both positive and negative roles for Ptk7 in canonical Wnt/ß-catenin signalling ... Furthermore, during late gastrula and segmentation stages, we observe significant upregulation of ß-catenin target gene expression and demonstrate a clear role for Ptk7 in attenuating canonical Wnt/ß-catenin activity in vivo