Gene interactions and pathways from curated databases and text-mining

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FOXO1 — XPO1

Pathways - manually collected, often from reviews:

  • NCI Pathway Database FoxO family signaling: Ran/GTP/Exportin 1 complex (RAN-XPO1) → FOXO1/14-3-3 family complex (FOXO1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (translocation, activates)
    Rena et al., EMBO J 2002
    Evidence: mutant phenotype, physical interaction