Gene interactions and pathways from curated databases and text-mining

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FOXO1 — ZGLP1

Text-mined interactions from Literome

Buteau et al., Diabetes 2006 : GLP-1 inhibited FoxO1 through phosphorylation dependent nuclear exclusion in pancreatic beta ( INS832/13 ) cells ... Gene expression and chromatin immunoprecipitation assays demonstrated that GLP-1 increases pancreatic and duodenal homeobox gene-1 and Foxa2 expression and inhibits FoxO1 binding to both promoters
Wang et al., Metabolism 2011 : The effects of GLP-1 and/or candesartan on glucolipotoxicity induced apoptosis and the phosphorylation of insulin receptor substrate-2 (IRS-2), protein kinase B (PKB), and forkhead box O1 (FoxO1) were evaluated by using MIN6 cells and isolated mouse pancreatic islets
Bastien-Dionne et al., Diabetes 2011 : We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the ß-cell