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MMP14 — PDGFB
Text-mined interactions from Literome
Stawowy et al., Biochem Biophys Res Commun 2004
:
Both, IGF-1 and
PDGF-BB , induced MT1-MMP expression, but only IGF-1 mediated
MT1-MMP induction was
inhibited by dec-CMK
van Roeyen et al., Kidney Int 2006
:
However, at the protein level, both
MMP-13 and -14 were equally
induced by
PDGF-BB and -DD
Karakiulakis et al., J Biol Chem 2007
(Anoxia) :
PDGF-BB inhibited the synthesis and secretion of all hypoxia dependent
MMP via Erk1/2 mitogen activated protein ( MAP ) kinase activation
Liu et al., Neurol Res 2008
(Disease Models, Animal...) :
So,
PDGF-B may
induce the expression of
MMP for the degradation of collagen type III on the wall of the saccular aneurysms
Sun et al., Cell Signal 2013
:
PDGF-BB induced
MT1-MMP expression regulates proliferation and invasion of mesenchymal stem cells in 3-dimensional collagen via MEK/ERK1/2 and PI3K/AKT signaling ...
PDGF-BB stimulates
MT1-MMP expression at both the mRNA and protein levels in concert with ERK1/2 and PI3K/AKT activation