Description: Homo sapiens caspase recruitment domain family, member 11 (CARD11), mRNA. RefSeq Summary (NM_032415): The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:2,945,710-3,083,509 Size: 137,800 Total Exon Count: 25 Strand: - Coding Region Position: hg19 chr7:2,946,272-2,998,140 Size: 51,869 Coding Exon Count: 24
ID:CAR11_HUMAN DESCRIPTION: RecName: Full=Caspase recruitment domain-containing protein 11; AltName: Full=CARD-containing MAGUK protein 1; Short=Carma 1; FUNCTION: Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. SUBUNIT: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail). SUBCELLULAR LOCATION: Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. TISSUE SPECIFICITY: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. PTM: Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling (By similarity). SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 1 PDZ (DHR) domain. CAUTION: Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. SEQUENCE CAUTION: Sequence=AAG53402.1; Type=Erroneous initiation; Sequence=AAI11720.2; Type=Erroneous initiation; Sequence=AAQ96893.1; Type=Erroneous gene model prediction; Sequence=EAL23962.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BXL7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001819 positive regulation of cytokine production GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002377 immunoglobulin production GO:0007165 signal transduction GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0030183 B cell differentiation GO:0030890 positive regulation of B cell proliferation GO:0031295 T cell costimulation GO:0038095 Fc-epsilon receptor signaling pathway GO:0038202 TORC1 signaling GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042981 regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045061 thymic T cell selection GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045577 regulation of B cell differentiation GO:0045580 regulation of T cell differentiation GO:0046037 GMP metabolic process GO:0046649 lymphocyte activation GO:0046710 GDP metabolic process GO:0048872 homeostasis of number of cells GO:0050776 regulation of immune response GO:0050852 T cell receptor signaling pathway GO:0050870 positive regulation of T cell activation GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0070970 interleukin-2 secretion
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
