Description: Homo sapiens glutamic-oxaloacetic transaminase 2, mitochondrial (GOT2), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_002080): Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]. Transcript (Including UTRs) Position: hg19 chr16:58,741,035-58,768,246 Size: 27,212 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr16:58,742,075-58,768,132 Size: 26,058 Coding Exon Count: 10
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GOT2 CDC HuGE Published Literature: GOT2 Positive Disease Associations: Aorta
, QT interval Related Studies:
Aorta Nathan E Wineinger et al. BMC medical genomics 2011, Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study., BMC medical genomics.
[PubMed 21223598]
The regions we discovered are candidates for future studies on cardiovascular outcomes, particularly in African Americans. The methods we employed can also provide an outline for genetic researchers interested in jointly testing SNP and CNV effects and/or applying mixed model procedures on a genome-wide scale.
QT interval Newton-Cheh ,et al. 2009, Common variants at ten loci influence QT interval duation in the QTGEN Study, Nature genetics 2009 41- 4 : 399-406.
[PubMed 19305408]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P00505
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.