Description: Homo sapiens kinesin family member 1B (KIF1B), transcript variant 1, mRNA. RefSeq Summary (NM_015074): This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:10,270,764-10,441,661 Size: 170,898 Total Exon Count: 47 Strand: + Coding Region Position: hg19 chr1:10,292,387-10,436,645 Size: 144,259 Coding Exon Count: 46
Body Mass Index Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
Carcinoma, Hepatocellular Hongxing Zhang et al. Nature genetics 2010, Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers., Nature genetics.
[PubMed 20676096]
Insulin James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903298]
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60333-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LP895698 - Sequence 562 from Patent EP3253886. AY139835 - Homo sapiens kinesin superfamily protein (KIF1B-alpha) mRNA, complete cds. AF257176 - Homo sapiens kinesin superfamily protein KIF1B mRNA, complete cds. AB011163 - Homo sapiens mRNA for KIAA0591 protein, partial cds. AB040881 - Homo sapiens KIAA1448 mRNA for KIAA1448 protein. BC115395 - Homo sapiens kinesin family member 1B, mRNA (cDNA clone MGC:134844 IMAGE:40067993), complete cds. AB017133 - Homo sapiens KIAA0591/KIF1Bbeta mRNA, complete cds. AY043362 - Homo sapiens kinesin superfamily protein 1B (KIF1B) mRNA, complete cds. AB384601 - Synthetic construct DNA, clone: pF1KA1448, Homo sapiens KIF1B gene for kinesin family member 1B, complete cds, without stop codon, in Flexi system. AB384504 - Synthetic construct DNA, clone: pF1KA0591, Homo sapiens KIF1B gene for kinesin family member 1B, complete cds, without stop codon, in Flexi system. AB088210 - Homo sapiens KIF1Bbeta mRNA for kinesin family member 1Bbeta isoform I, complete cds. AB088211 - Homo sapiens KIF1Bbeta mRNA for kinesin family member 1Bbeta isoform II, complete cds. AB088212 - Homo sapiens KIF1Bbeta mRNA for kinesin family member 1Bbeta isoform III, complete cds. AB088213 - Homo sapiens KIF1Bbeta mRNA for kinesin family member 1Bbeta isoform IV, complete cds. AK308121 - Homo sapiens cDNA, FLJ98069. JD210303 - Sequence 191327 from Patent EP1572962. JD199364 - Sequence 180388 from Patent EP1572962. AK297439 - Homo sapiens cDNA FLJ58122 complete cds, highly similar to Kinesin-like protein KIF1B. AK074279 - Homo sapiens cDNA FLJ23699 fis, clone HEP10674, highly similar to Homo sapiens kinesin superfamily protein KIF1B mRNA. BC001415 - Homo sapiens kinesin family member 1B, mRNA (cDNA clone IMAGE:3139918), complete cds. CU674694 - Synthetic construct Homo sapiens gateway clone IMAGE:100017716 5' read KIF1B mRNA. BT007174 - Homo sapiens kinesin family member 1B mRNA, complete cds. KJ902280 - Synthetic construct Homo sapiens clone ccsbBroadEn_11674 KIF1B gene, encodes complete protein. KR710781 - Synthetic construct Homo sapiens clone CCSBHm_00016943 KIF1B (KIF1B) mRNA, encodes complete protein. AK054955 - Homo sapiens cDNA FLJ30393 fis, clone BRACE2008361, weakly similar to Mus musculus mRNA for KIF1B-beta. AK022977 - Homo sapiens cDNA FLJ12915 fis, clone NT2RP2004538, highly similar to Mus musculus kinesin-like protein KIF1B (Kif1b) mRNA. JD307763 - Sequence 288787 from Patent EP1572962. JD165926 - Sequence 146950 from Patent EP1572962. JD315862 - Sequence 296886 from Patent EP1572962. JD506702 - Sequence 487726 from Patent EP1572962. JD116275 - Sequence 97299 from Patent EP1572962. JD183050 - Sequence 164074 from Patent EP1572962. JD090233 - Sequence 71257 from Patent EP1572962. JD566922 - Sequence 547946 from Patent EP1572962. JD499428 - Sequence 480452 from Patent EP1572962. JD515927 - Sequence 496951 from Patent EP1572962. JD376180 - Sequence 357204 from Patent EP1572962. JD214312 - Sequence 195336 from Patent EP1572962. JD044608 - Sequence 25632 from Patent EP1572962. JD396747 - Sequence 377771 from Patent EP1572962. JD546784 - Sequence 527808 from Patent EP1572962. DQ578101 - Homo sapiens piRNA piR-46213, complete sequence. JD238811 - Sequence 219835 from Patent EP1572962. JD542707 - Sequence 523731 from Patent EP1572962. JD212668 - Sequence 193692 from Patent EP1572962. JD198044 - Sequence 179068 from Patent EP1572962. JD413333 - Sequence 394357 from Patent EP1572962. JD246833 - Sequence 227857 from Patent EP1572962. JD246834 - Sequence 227858 from Patent EP1572962. JD259090 - Sequence 240114 from Patent EP1572962. JD417699 - Sequence 398723 from Patent EP1572962. JD258459 - Sequence 239483 from Patent EP1572962. JD411961 - Sequence 392985 from Patent EP1572962. JD313332 - Sequence 294356 from Patent EP1572962. JD473596 - Sequence 454620 from Patent EP1572962. JD052750 - Sequence 33774 from Patent EP1572962. JD194787 - Sequence 175811 from Patent EP1572962. JD280196 - Sequence 261220 from Patent EP1572962. JD554179 - Sequence 535203 from Patent EP1572962. JD561260 - Sequence 542284 from Patent EP1572962. JD421446 - Sequence 402470 from Patent EP1572962. JD179064 - Sequence 160088 from Patent EP1572962. JD339471 - Sequence 320495 from Patent EP1572962. JD177489 - Sequence 158513 from Patent EP1572962. JD096440 - Sequence 77464 from Patent EP1572962. JD308917 - Sequence 289941 from Patent EP1572962. JD332371 - Sequence 313395 from Patent EP1572962. JD448358 - Sequence 429382 from Patent EP1572962. JD351761 - Sequence 332785 from Patent EP1572962. AK025761 - Homo sapiens cDNA: FLJ22108 fis, clone HEP17933. BC047632 - Homo sapiens kinesin family member 1B, mRNA (cDNA clone IMAGE:4817015). DQ586018 - Homo sapiens piRNA piR-53130, complete sequence. DQ591240 - Homo sapiens piRNA piR-58352, complete sequence. AK025771 - Homo sapiens cDNA: FLJ22118 fis, clone HEP18789. DQ585306 - Homo sapiens piRNA piR-52418, complete sequence. JD324246 - Sequence 305270 from Patent EP1572962. JD413363 - Sequence 394387 from Patent EP1572962. JD182684 - Sequence 163708 from Patent EP1572962. JD084227 - Sequence 65251 from Patent EP1572962. JD246884 - Sequence 227908 from Patent EP1572962. JD421864 - Sequence 402888 from Patent EP1572962. JD446318 - Sequence 427342 from Patent EP1572962. JD446317 - Sequence 427341 from Patent EP1572962. JD170850 - Sequence 151874 from Patent EP1572962. JD217806 - Sequence 198830 from Patent EP1572962. JD294109 - Sequence 275133 from Patent EP1572962. JD278834 - Sequence 259858 from Patent EP1572962. JD540399 - Sequence 521423 from Patent EP1572962. JD421452 - Sequence 402476 from Patent EP1572962. JD179071 - Sequence 160095 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60333 (Reactome details) participates in the following event(s):
R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-109582 Hemostasis R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport