Description: Homo sapiens paralemmin (PALM), transcript variant 1, mRNA. RefSeq Summary (NM_002579): This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:708,953-748,330 Size: 39,378 Total Exon Count: 9 Strand: + Coding Region Position: hg19 chr19:709,147-746,814 Size: 37,668 Coding Exon Count: 9
ID:PALM_HUMAN DESCRIPTION: RecName: Full=Paralemmin-1; AltName: Full=Paralemmin; Flags: Precursor; FUNCTION: Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. SUBUNIT: Interacts with dopamine receptor DRD3. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Basolateral cell membrane; Lipid-anchor (By similarity). Apicolateral cell membrane; Lipid-anchor (By similarity). Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. TISSUE SPECIFICITY: Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland. SIMILARITY: Belongs to the paralemmin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75781
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
