Description: Homo sapiens serine/threonine kinase 31 (STK31), transcript variant 1, mRNA. RefSeq Summary (NM_031414): This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr7:23,749,786-23,872,130 Size: 122,345 Total Exon Count: 24 Strand: + Coding Region Position: hg19 chr7:23,749,905-23,871,985 Size: 122,081 Coding Exon Count: 24
ID:STK31_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 31; EC=2.7.11.1; AltName: Full=Serine/threonine-protein kinase NYD-SPK; AltName: Full=Sugen kinase 396; Short=SgK396; CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. TISSUE SPECIFICITY: Testis specific. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 Tudor domain. CAUTION: Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.
Heart Rate Christopher Newton-Cheh et al. BMC medical genetics 2007, Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study., BMC medical genetics.
[PubMed 17903306]
In the community-based Framingham Heart Study none of the ECG and HRV results individually attained genomewide significance. However, the presence of bona fide QT-associated SNPs among the top 117 results for QT duration supports the importance of efforts to validate top results from the reported scans. Finding genetic variants associated with ECG and HRV quantitative traits may identify novel genes and pathways implicated in arrhythmogenesis and allow for improved recognition of individuals at high risk for arrhythmias in the general population.
Mental Competency Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF00567 - Tudor domain PF07714 - Protein tyrosine kinase
SCOP Domains: 63748 - Tudor/PWWP/MBT 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9BXU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.