Description: Homo sapiens transcription elongation factor A (SII), 2 (TCEA2), transcript variant 1, mRNA. RefSeq Summary (NM_003195): The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr20:62,694,010-62,703,700 Size: 9,691 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr20:62,694,666-62,703,533 Size: 8,868 Coding Exon Count: 10
ID:TCEA2_HUMAN DESCRIPTION: RecName: Full=Transcription elongation factor A protein 2; AltName: Full=Testis-specific S-II; AltName: Full=Transcription elongation factor S-II protein 2; AltName: Full=Transcription elongation factor TFIIS.l; FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. SUBUNIT: Interacts with the basal transcription factor GTF2B. Interacts with REXO1. INTERACTION: P43364:MAGEA11; NbExp=2; IntAct=EBI-710310, EBI-739552; P27448:MARK3; NbExp=2; IntAct=EBI-710310, EBI-707595; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis and ovary specific. SIMILARITY: Belongs to the TFS-II family. SIMILARITY: Contains 1 TFIIS central domain. SIMILARITY: Contains 1 TFIIS N-terminal domain. SIMILARITY: Contains 1 TFIIS-type zinc finger. CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. SEQUENCE CAUTION: Sequence=CAD11900.1; Type=Erroneous gene model prediction; Sequence=CAD11901.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15560
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
