Description: Homo sapiens unc-45 homolog A (C. elegans) (UNC45A), transcript variant 2, mRNA. RefSeq Summary (NM_018671): This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]. Transcript (Including UTRs) Position: hg19 chr15:91,478,215-91,497,323 Size: 19,109 Total Exon Count: 20 Strand: + Coding Region Position: hg19 chr15:91,478,555-91,496,946 Size: 18,392 Coding Exon Count: 20
ID:UN45A_HUMAN DESCRIPTION: RecName: Full=Protein unc-45 homolog A; Short=Unc-45A; AltName: Full=GCUNC-45; AltName: Full=Smooth muscle cell-associated protein 1; Short=SMAP-1; FUNCTION: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). SUBUNIT: Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus. TISSUE SPECIFICITY: Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H3U1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007275 multicellular organism development GO:0007517 muscle organ development GO:0030154 cell differentiation GO:0061077 chaperone-mediated protein folding
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
