Description: Homo sapiens voltage-dependent anion channel 3 (VDAC3), transcript variant 1, mRNA. RefSeq Summary (NM_005662): This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. Transcript (Including UTRs) Position: hg19 chr8:42,249,279-42,263,455 Size: 14,177 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr8:42,251,730-42,262,980 Size: 11,251 Coding Exon Count: 8
ID:VDAC3_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent anion-selective channel protein 3; Short=VDAC-3; Short=hVDAC3; AltName: Full=Outer mitochondrial membrane protein porin 3; FUNCTION: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane. TISSUE SPECIFICITY: Widely expressed. Highest in testis. DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity). SIMILARITY: Belongs to the eukaryotic mitochondrial porin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y277
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCyc Knowledge Library PWY3DJ-471 - creatine-phosphate energy transfer
Reactome (by CSHL, EBI, and GO)
Protein Q9Y277 (Reactome details) participates in the following event(s):
R-HSA-8949145 VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space R-HSA-5696872 USP30 deubiquitinates Ub-MOM proteins R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-5689880 Ub-specific processing proteases R-HSA-382551 Transport of small molecules R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
