Gene interactions and pathways from curated databases and text-mining
Proc Natl Acad Sci U S A 2006, PMID: 16595631

Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide.

Schreiber, Joerg; Jenner, Richard G; Murray, Heather L; Gerber, Georg K; Gifford, David K; Young, Richard A

The NF-kappaB family of transcription factors plays a critical role in numerous cellular processes, particularly the immune response. Our understanding of how the different NF-kappaB subunits act coordinately to regulate gene expression is based on a limited set of genes. We used genome-scale location analysis to identify targets of all five NF-kappaB proteins before and after stimulation of monocytic cells with bacterial lipopolysaccharide (LPS). In unstimulated cells, p50 and p52 bound to a large number of gene promoters that were also occupied by RNA polymerase II. After LPS stimulation, additional NF-kappaB subunits bound to these genes and to other genes. Genes that became bound by multiple NF-kappaB subunits were the most likely to show increases in RNA polymerase II occupancy and gene expression. This study identifies NF-kappaB target genes, reveals how the different NF-kappaB proteins coordinate their activity, and provides an initial map of the transcriptional regulatory network that underlies the host response to infection.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • FastForward regulation: NFKB1 → CREB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → DR1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → ELF3 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → NFATC2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → NFKB2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → NFKBIB (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → ZNF395 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → RB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → PRDM1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → SREBF2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → SRF (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → STAT5A (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → VAV1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → ZFHX2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → BAZ1B (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB1 → NR1D1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB2 → CREB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB2 → NFKB2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: NFKB2 → ZNF395 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → CREB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → ATF6 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → JUN (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → NFKB2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → NFKBIB (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → BCL6 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → SREBF2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → STAT1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → STAT5A (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → TFE3 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → VAV1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELB → ZFHX2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: FLI1 → EGR1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: FLI1 → FOS (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → KLF15 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → NFKB2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → NFKBIB (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → RB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → STAT6 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → TFAP2A (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → VAV1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: RELA → ZNF76 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → CREB1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → ELK1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → NFKB2 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → STAT1 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → STAT5A (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → ZNF76 (transcriptional regulation, unknown)
    Evidence: DNABINDING
  • FastForward regulation: REL → RFXANK (transcriptional regulation, unknown)
    Evidence: DNABINDING
In total, 48 gene pairs are associated to this article in curated databases