FEBS Lett 2012,
PMID: 22819820
Zeng, Bing; Li, Zhihua; Chen, Rufu; Guo, Ning; Zhou, Jiajia; Zhou, Quanbo; Lin, Qing; Cheng, Di; Liao, Qiaofang; Zheng, Liping; Gong, Yuanfeng
Hepatitis C Virus core protein (HCVc) plays important roles in the development of intrahepatic cholangiocarcinoma (ICC). MicroRNAs (miRNAs) contribute to tumor progression by interacting with downstream target genes. However, the regulation and role of miRNAs in HCV-related intrahepatic cholangiocarcinoma (HCV-ICC) is poorly understood. In this study, we found that miR-124 was down-regulated in HCV-ICC and the induction of DNMT1 by HCVc mediated the suppression of miR-124. Over-expression of miR-124 suppressed cell migration and invasion in vitro, and reduced the protein levels of SMYD3 and downstream target genes (c-Myc and MMP9). Knockdown of SMYD3 inhibited cell migration and invasion resembling that of miR-124 over-expression. In conclusion, our studies indicate that low miR-124 levels mediated by HCVc via DNMT1 promote ICC cell migration and invasion by targeting SMYD3.
Diseases/Pathways annotated by Medline MESH: Cholangiocarcinoma, Liver Neoplasms, Neoplasm Invasiveness
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Text Mining Data
miR-124 ⊣ DNMT1: "
In this study, we found that miR-124 was down-regulated in HCV-ICC and the induction of
DNMT1 by HCVc
mediated the suppression of
miR-124
"
SMYD3 ⊣ miR-124: "
Over-expression of miR-124 suppressed cell migration and invasion in vitro, and reduced the protein levels of SMYD3 and downstream target genes ( c-Myc and MMP9 )
"
Manually curated Databases
No curated data.