Cell Immunol 1985,
PMID: 3873997
Sarlo, K T; Mortensen, R F
Purified serum amyloid P component (SAP), the major acute-phase reactant of mice, induces enhanced interleukin 1 (IL-1) production by elicited monocytes/macrophages in vitro. SAP also enhanced IL-1 elaboration by macrophages from lipopolysaccharide (LPS)-low responder mice and in the presence of polymyxin B, indicating that the small amounts of LPS present in the SAP preparation did not augment IL-1 production. Concentrations of SAP of 0.1 to 10.0 micrograms/ml enhanced IL-1 production by elicited and bacillus Calmette-Guerin (BCG)-activated peritoneal macrophages, but not by resident peritoneal macrophages. The inflammation-induced monocyte/macrophage population displayed selective binding of SAP. The mouse macrophage line P388D1, also could bind SAP and display enhanced IL-1 production in response to SAP. SAP did not bind to the macrophage cell line RAW264.7 nor did it enhance IL-1 secretion by this line. The results suggest that this acute-phase reactant has the potential to enhance inflammatory and immunological events mediated by IL-1.
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Text Mining Data
interleukin 1 (IL-1) → serum amyloid P component (SAP): "
Purified
serum amyloid P component (SAP) , the major acute-phase reactant of mice,
induces enhanced
interleukin 1 (IL-1) production by elicited monocytes/macrophages in vitro
"
IL-1 → SAP: "
The mouse macrophage line P388D1, also could bind SAP and display enhanced IL-1 production in response to SAP
"
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