J Cell Sci 1998,
PMID: 9394011
Röttger, S; White, J; Wandall, H H; Olivo, J C; Stark, A; Bennett, E P; Whitehouse, C; Berger, E G; Clausen, H; Nilsson, T
O-glycosylation of proteins is initiated by a family of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactos-aminyltransferases (GalNAc-T). In this study, we have localized endogenous and epitope-tagged human GalNAc-T1, -T2 and -T3 to the Golgi apparatus in HeLa cells by subcellular fractionation, immunofluorescence and immunoelectron microscopy. We show that all three GalNAc-transferases are concentrated about tenfold in Golgi stacks over Golgi associated tubular-vesicular membrane structures. Surprisingly, we find that GalNAc-T1, -T2 and -T3 are present throughout the Golgi stack suggesting that initiation of O-glycosylation may not be restricted to the cis Golgi, but occur at multiple sites within the Golgi apparatus. GalNAc-T1 distributes evenly across the Golgi stack whereas GalNAc-T2 and -T3 reside preferentially on the trans side and in the medial part of the Golgi stack, respectively. Moreover, we have investigated the possibility of O-glycan initiation in pre-Golgi compartments such as the ER. We could not detect endogenous polypeptide GalNAc-transferase activity in the ER of HeLa cells, neither by subcellular fractionation nor by situ glycosylation of an ER-retained form of CD8 (CD8/E19). However, upon relocation of chimeric GalNAc-T1 or -T2 to the ER, CD8/E19 is glycosylated with different efficiencies indicating that all components required for initiation of O-glycosylation are present in the ER except for polypeptide GalNAc-transferases.
Document information provided by NCBI PubMed
Text Mining Data
Dashed line = No text mining data
Manually curated Databases
-
Reactome Reaction:
GALNT10
→
MUC12
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT1
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC7
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT9
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC21
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT14
(reaction)
-
Reactome Reaction:
GALNT12
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC17
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC7
(reaction)
-
Reactome Reaction:
MUC2
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT10
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC20
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC12
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT10
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC17
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT8
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC16
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT3
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC13
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT10
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC15
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT9
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC6
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT11
(reaction)
-
Reactome Reaction:
GALNT13
→
MUCL1
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT9
(reaction)
-
Reactome Reaction:
GALNT4
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT10
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC17
(reaction)
-
Reactome Reaction:
MUC5B
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC13
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT7
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC20
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT4
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC20
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT2
→
MUCL1
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT2
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC17
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT14
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT6
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT15
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC13
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT2
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC20
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT14
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT15
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT5
(reaction)
-
Reactome Reaction:
GALNT7
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC21
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT14
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC20
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT4
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT5
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT3
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT9
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT6
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT15
→
MUCL1
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC15
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT7
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC20
(reaction)
-
Reactome Reaction:
MUC13
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC20
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT1
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT9
→
MUCL1
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC20
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT3
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC7
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT3
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT11
→
MUCL1
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT1
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT2
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT4
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT2
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC15
(reaction)
-
Reactome Reaction:
MUC15
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT6
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT3
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC13
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT7
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT5
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC16
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT4
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC4
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT13
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT8
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC4
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT12
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC13
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT12
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC6
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT13
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC3B
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT7
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC15
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT13
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT5
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC4
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT15
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC12
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT1
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC16
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT8
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC19
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT6
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC6
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT12
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC7
(reaction)
-
Reactome Reaction:
MUC3A
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT1
→
MUCL1
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT6
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC21
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT11
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT10
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT8
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC4
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT15
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC17
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC15
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT9
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT8
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC16
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT12
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC12
(reaction)
-
Reactome Reaction:
MUC5AC
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT7
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC3B
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT15
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC17
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT13
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC13
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC6
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT12
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC3B
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC6
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT11
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC15
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT11
(reaction)
-
Reactome Reaction:
GALNT10
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC21
(reaction)
-
Reactome Reaction:
GALNT6
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT9
→
MUC12
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT4
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC16
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT10
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT5
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC4
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC13
(reaction)
-
Reactome Reaction:
GALNT5
→
MUC7
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT1
→
MUC6
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC13
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT13
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT13
→
MUC12
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT2
(reaction)
-
Reactome Reaction:
GALNT11
→
MUC17
(reaction)
-
Reactome Reaction:
GALNT12
→
MUC20
(reaction)
-
Reactome Reaction:
C1GALT1C1
→
MUC20
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC16
(reaction)
-
Reactome Reaction:
GALNT4
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC19
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC3B
(reaction)
-
Reactome Reaction:
MUC1
→
GALNT14
(reaction)
-
Reactome Reaction:
GALNT14
→
MUCL1
(reaction)
-
Reactome Reaction:
GALNT2
→
MUC17
(reaction)
-
Reactome Reaction:
MUC5B
→
GALNT3
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT15
→
MUC15
(reaction)
-
Reactome Reaction:
GALNT8
→
MUC13
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT6
(reaction)
-
Reactome Reaction:
MUC1
→
C1GALT1C1
(reaction)
-
Reactome Reaction:
MUC2
→
GALNT8
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT11
(reaction)
-
Reactome Reaction:
MUC3A
→
GALNT5
(reaction)
-
Reactome Reaction:
GALNT7
→
MUC12
(reaction)
-
Reactome Reaction:
GALNT14
→
MUC7
(reaction)
-
Reactome Reaction:
MUC5AC
→
GALNT1
(reaction)
-
Reactome Reaction:
GALNT3
→
MUC15
(reaction)
In total, 288 gene pairs are associated to this article in curated databases