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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
J Cell Sci 1998, PMID: 9394011

Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

Röttger, S; White, J; Wandall, H H; Olivo, J C; Stark, A; Bennett, E P; Whitehouse, C; Berger, E G; Clausen, H; Nilsson, T

O-glycosylation of proteins is initiated by a family of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactos-aminyltransferases (GalNAc-T). In this study, we have localized endogenous and epitope-tagged human GalNAc-T1, -T2 and -T3 to the Golgi apparatus in HeLa cells by subcellular fractionation, immunofluorescence and immunoelectron microscopy. We show that all three GalNAc-transferases are concentrated about tenfold in Golgi stacks over Golgi associated tubular-vesicular membrane structures. Surprisingly, we find that GalNAc-T1, -T2 and -T3 are present throughout the Golgi stack suggesting that initiation of O-glycosylation may not be restricted to the cis Golgi, but occur at multiple sites within the Golgi apparatus. GalNAc-T1 distributes evenly across the Golgi stack whereas GalNAc-T2 and -T3 reside preferentially on the trans side and in the medial part of the Golgi stack, respectively. Moreover, we have investigated the possibility of O-glycan initiation in pre-Golgi compartments such as the ER. We could not detect endogenous polypeptide GalNAc-transferase activity in the ER of HeLa cells, neither by subcellular fractionation nor by situ glycosylation of an ER-retained form of CD8 (CD8/E19). However, upon relocation of chimeric GalNAc-T1 or -T2 to the ER, CD8/E19 is glycosylated with different efficiencies indicating that all components required for initiation of O-glycosylation are present in the ER except for polypeptide GalNAc-transferases.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: GALNT10 → MUC12 (reaction)
  • Reactome Reaction: MUC5B → GALNT1 (reaction)
  • Reactome Reaction: GALNT14 → MUC15 (reaction)
  • Reactome Reaction: GALNT3 → MUC7 (reaction)
  • Reactome Reaction: MUC2 → GALNT9 (reaction)
  • Reactome Reaction: GALNT2 → MUC4 (reaction)
  • Reactome Reaction: GALNT6 → MUC21 (reaction)
  • Reactome Reaction: MUC5AC → GALNT14 (reaction)
  • Reactome Reaction: GALNT12 → MUCL1 (reaction)
  • Reactome Reaction: GALNT14 → MUC17 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC7 (reaction)
  • Reactome Reaction: MUC2 → C1GALT1C1 (reaction)
  • Reactome Reaction: MUC2 → GALNT10 (reaction)
  • Reactome Reaction: GALNT15 → MUC13 (reaction)
  • Reactome Reaction: GALNT1 → MUC3B (reaction)
  • Reactome Reaction: GALNT15 → MUC20 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC12 (reaction)
  • Reactome Reaction: MUC5B → GALNT10 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC4 (reaction)
  • Reactome Reaction: GALNT13 → MUC15 (reaction)
  • Reactome Reaction: GALNT14 → MUC19 (reaction)
  • Reactome Reaction: GALNT12 → MUC17 (reaction)
  • Reactome Reaction: MUC5B → GALNT8 (reaction)
  • Reactome Reaction: GALNT6 → MUC4 (reaction)
  • Reactome Reaction: GALNT12 → MUC16 (reaction)
  • Reactome Reaction: MUC5AC → GALNT3 (reaction)
  • Reactome Reaction: GALNT6 → MUC17 (reaction)
  • Reactome Reaction: GALNT4 → MUC3B (reaction)
  • Reactome Reaction: GALNT5 → MUC13 (reaction)
  • Reactome Reaction: MUC1 → GALNT10 (reaction)
  • Reactome Reaction: GALNT12 → MUC15 (reaction)
  • Reactome Reaction: MUC5AC → GALNT9 (reaction)
  • Reactome Reaction: GALNT3 → MUC20 (reaction)
  • Reactome Reaction: GALNT6 → MUC6 (reaction)
  • Reactome Reaction: MUC1 → GALNT11 (reaction)
  • Reactome Reaction: GALNT13 → MUCL1 (reaction)
  • Reactome Reaction: MUC3A → GALNT9 (reaction)
  • Reactome Reaction: GALNT4 → MUCL1 (reaction)
  • Reactome Reaction: GALNT5 → MUC17 (reaction)
  • Reactome Reaction: GALNT10 → MUCL1 (reaction)
  • Reactome Reaction: GALNT15 → MUC17 (reaction)
  • Reactome Reaction: MUC5B → C1GALT1C1 (reaction)
  • Reactome Reaction: GALNT5 → MUC19 (reaction)
  • Reactome Reaction: GALNT3 → MUC13 (reaction)
  • Reactome Reaction: MUC2 → GALNT7 (reaction)
  • Reactome Reaction: GALNT4 → MUC4 (reaction)
  • Reactome Reaction: GALNT8 → MUC20 (reaction)
  • Reactome Reaction: MUC3A → GALNT4 (reaction)
  • Reactome Reaction: GALNT9 → MUC3B (reaction)
  • Reactome Reaction: GALNT10 → MUC20 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC17 (reaction)
  • Reactome Reaction: GALNT4 → MUC16 (reaction)
  • Reactome Reaction: GALNT14 → MUC6 (reaction)
  • Reactome Reaction: GALNT11 → MUC19 (reaction)
  • Reactome Reaction: GALNT12 → MUC19 (reaction)
  • Reactome Reaction: GALNT5 → MUC6 (reaction)
  • Reactome Reaction: GALNT2 → MUCL1 (reaction)
  • Reactome Reaction: MUC2 → GALNT2 (reaction)
  • Reactome Reaction: GALNT14 → MUC16 (reaction)
  • Reactome Reaction: GALNT13 → MUC3B (reaction)
  • Reactome Reaction: GALNT4 → MUC7 (reaction)
  • Reactome Reaction: GALNT8 → MUC17 (reaction)
  • Reactome Reaction: MUC5B → GALNT14 (reaction)
  • Reactome Reaction: MUC2 → GALNT6 (reaction)
  • Reactome Reaction: MUC3A → GALNT15 (reaction)
  • Reactome Reaction: GALNT7 → MUC13 (reaction)
  • Reactome Reaction: MUC5AC → GALNT2 (reaction)
  • Reactome Reaction: GALNT9 → MUC20 (reaction)
  • Reactome Reaction: MUC3A → GALNT14 (reaction)
  • Reactome Reaction: MUC2 → GALNT15 (reaction)
  • Reactome Reaction: MUC2 → GALNT5 (reaction)
  • Reactome Reaction: GALNT7 → MUCL1 (reaction)
  • Reactome Reaction: GALNT12 → MUC21 (reaction)
  • Reactome Reaction: MUC2 → GALNT14 (reaction)
  • Reactome Reaction: GALNT1 → MUC20 (reaction)
  • Reactome Reaction: MUC2 → GALNT4 (reaction)
  • Reactome Reaction: MUC5AC → GALNT5 (reaction)
  • Reactome Reaction: MUC3A → GALNT3 (reaction)
  • Reactome Reaction: MUC5B → GALNT9 (reaction)
  • Reactome Reaction: MUC3A → GALNT6 (reaction)
  • Reactome Reaction: GALNT9 → MUC7 (reaction)
  • Reactome Reaction: GALNT3 → MUC12 (reaction)
  • Reactome Reaction: GALNT10 → MUC19 (reaction)
  • Reactome Reaction: GALNT8 → MUC21 (reaction)
  • Reactome Reaction: GALNT9 → MUC17 (reaction)
  • Reactome Reaction: GALNT15 → MUCL1 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC16 (reaction)
  • Reactome Reaction: GALNT6 → MUC13 (reaction)
  • Reactome Reaction: GALNT5 → MUC15 (reaction)
  • Reactome Reaction: MUC5AC → GALNT7 (reaction)
  • Reactome Reaction: GALNT6 → MUC19 (reaction)
  • Reactome Reaction: GALNT5 → MUC20 (reaction)
  • Reactome Reaction: MUC13 → C1GALT1C1 (reaction)
  • Reactome Reaction: GALNT15 → MUC21 (reaction)
  • Reactome Reaction: GALNT4 → MUC6 (reaction)
  • Reactome Reaction: GALNT4 → MUC20 (reaction)
  • Reactome Reaction: MUC1 → GALNT1 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC3B (reaction)
  • Reactome Reaction: GALNT9 → MUCL1 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC21 (reaction)
  • Reactome Reaction: GALNT5 → MUC16 (reaction)
  • Reactome Reaction: GALNT13 → MUC20 (reaction)
  • Reactome Reaction: MUC1 → GALNT3 (reaction)
  • Reactome Reaction: GALNT3 → MUC17 (reaction)
  • Reactome Reaction: GALNT2 → MUC7 (reaction)
  • Reactome Reaction: MUC2 → GALNT3 (reaction)
  • Reactome Reaction: GALNT2 → MUC16 (reaction)
  • Reactome Reaction: GALNT11 → MUCL1 (reaction)
  • Reactome Reaction: MUC2 → GALNT1 (reaction)
  • Reactome Reaction: MUC3A → GALNT2 (reaction)
  • Reactome Reaction: MUC5B → GALNT4 (reaction)
  • Reactome Reaction: MUC1 → GALNT2 (reaction)
  • Reactome Reaction: GALNT12 → MUC4 (reaction)
  • Reactome Reaction: GALNT13 → MUC21 (reaction)
  • Reactome Reaction: GALNT3 → MUC19 (reaction)
  • Reactome Reaction: GALNT2 → MUC15 (reaction)
  • Reactome Reaction: MUC15 → C1GALT1C1 (reaction)
  • Reactome Reaction: GALNT1 → MUC15 (reaction)
  • Reactome Reaction: GALNT6 → MUCL1 (reaction)
  • Reactome Reaction: GALNT4 → MUC15 (reaction)
  • Reactome Reaction: GALNT10 → MUC7 (reaction)
  • Reactome Reaction: GALNT11 → MUC3B (reaction)
  • Reactome Reaction: GALNT11 → MUC16 (reaction)
  • Reactome Reaction: GALNT1 → MUC16 (reaction)
  • Reactome Reaction: GALNT13 → MUC7 (reaction)
  • Reactome Reaction: GALNT14 → MUC13 (reaction)
  • Reactome Reaction: GALNT15 → MUC6 (reaction)
  • Reactome Reaction: GALNT3 → MUCL1 (reaction)
  • Reactome Reaction: GALNT9 → MUC21 (reaction)
  • Reactome Reaction: GALNT8 → MUC12 (reaction)
  • Reactome Reaction: GALNT11 → MUC15 (reaction)
  • Reactome Reaction: GALNT10 → MUC13 (reaction)
  • Reactome Reaction: MUC5B → GALNT7 (reaction)
  • Reactome Reaction: GALNT9 → MUC16 (reaction)
  • Reactome Reaction: GALNT8 → MUC16 (reaction)
  • Reactome Reaction: GALNT1 → MUC17 (reaction)
  • Reactome Reaction: GALNT1 → MUC21 (reaction)
  • Reactome Reaction: GALNT5 → MUCL1 (reaction)
  • Reactome Reaction: GALNT6 → MUC16 (reaction)
  • Reactome Reaction: MUC5AC → GALNT4 (reaction)
  • Reactome Reaction: GALNT11 → MUC7 (reaction)
  • Reactome Reaction: GALNT5 → MUC12 (reaction)
  • Reactome Reaction: GALNT8 → MUC3B (reaction)
  • Reactome Reaction: GALNT7 → MUC3B (reaction)
  • Reactome Reaction: GALNT3 → MUC16 (reaction)
  • Reactome Reaction: GALNT2 → MUC3B (reaction)
  • Reactome Reaction: GALNT13 → MUC17 (reaction)
  • Reactome Reaction: GALNT10 → MUC4 (reaction)
  • Reactome Reaction: GALNT8 → MUC4 (reaction)
  • Reactome Reaction: GALNT10 → MUC6 (reaction)
  • Reactome Reaction: GALNT15 → MUC4 (reaction)
  • Reactome Reaction: GALNT11 → MUC6 (reaction)
  • Reactome Reaction: GALNT13 → MUC19 (reaction)
  • Reactome Reaction: GALNT11 → MUC4 (reaction)
  • Reactome Reaction: MUC1 → GALNT13 (reaction)
  • Reactome Reaction: GALNT11 → MUC21 (reaction)
  • Reactome Reaction: GALNT12 → MUC7 (reaction)
  • Reactome Reaction: GALNT1 → MUC13 (reaction)
  • Reactome Reaction: GALNT7 → MUC17 (reaction)
  • Reactome Reaction: GALNT2 → MUC20 (reaction)
  • Reactome Reaction: GALNT9 → MUC13 (reaction)
  • Reactome Reaction: GALNT8 → MUCL1 (reaction)
  • Reactome Reaction: GALNT4 → MUC19 (reaction)
  • Reactome Reaction: GALNT9 → MUC4 (reaction)
  • Reactome Reaction: MUC1 → GALNT12 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUCL1 (reaction)
  • Reactome Reaction: GALNT13 → MUC13 (reaction)
  • Reactome Reaction: MUC2 → GALNT12 (reaction)
  • Reactome Reaction: GALNT8 → MUC6 (reaction)
  • Reactome Reaction: MUC3A → GALNT13 (reaction)
  • Reactome Reaction: GALNT12 → MUC3B (reaction)
  • Reactome Reaction: MUC1 → GALNT7 (reaction)
  • Reactome Reaction: GALNT6 → MUC15 (reaction)
  • Reactome Reaction: MUC5AC → GALNT13 (reaction)
  • Reactome Reaction: MUC1 → GALNT5 (reaction)
  • Reactome Reaction: GALNT6 → MUC7 (reaction)
  • Reactome Reaction: GALNT7 → MUC4 (reaction)
  • Reactome Reaction: MUC5B → GALNT15 (reaction)
  • Reactome Reaction: GALNT2 → MUC12 (reaction)
  • Reactome Reaction: GALNT15 → MUC12 (reaction)
  • Reactome Reaction: MUC3A → GALNT1 (reaction)
  • Reactome Reaction: GALNT5 → MUC3B (reaction)
  • Reactome Reaction: GALNT6 → MUC12 (reaction)
  • Reactome Reaction: GALNT10 → MUC21 (reaction)
  • Reactome Reaction: GALNT7 → MUC16 (reaction)
  • Reactome Reaction: MUC3A → GALNT8 (reaction)
  • Reactome Reaction: GALNT9 → MUC19 (reaction)
  • Reactome Reaction: GALNT7 → MUC19 (reaction)
  • Reactome Reaction: MUC1 → GALNT6 (reaction)
  • Reactome Reaction: GALNT13 → MUC4 (reaction)
  • Reactome Reaction: GALNT9 → MUC6 (reaction)
  • Reactome Reaction: MUC3A → GALNT12 (reaction)
  • Reactome Reaction: GALNT1 → MUC19 (reaction)
  • Reactome Reaction: GALNT2 → MUC13 (reaction)
  • Reactome Reaction: GALNT15 → MUC7 (reaction)
  • Reactome Reaction: GALNT14 → MUC3B (reaction)
  • Reactome Reaction: GALNT1 → MUC7 (reaction)
  • Reactome Reaction: MUC3A → C1GALT1C1 (reaction)
  • Reactome Reaction: GALNT5 → MUC21 (reaction)
  • Reactome Reaction: GALNT1 → MUCL1 (reaction)
  • Reactome Reaction: MUC5B → GALNT6 (reaction)
  • Reactome Reaction: GALNT7 → MUC21 (reaction)
  • Reactome Reaction: MUC2 → GALNT11 (reaction)
  • Reactome Reaction: MUC5AC → GALNT10 (reaction)
  • Reactome Reaction: MUC1 → GALNT8 (reaction)
  • Reactome Reaction: GALNT14 → MUC4 (reaction)
  • Reactome Reaction: MUC5AC → GALNT15 (reaction)
  • Reactome Reaction: GALNT3 → MUC4 (reaction)
  • Reactome Reaction: GALNT4 → MUC17 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC19 (reaction)
  • Reactome Reaction: GALNT6 → MUC3B (reaction)
  • Reactome Reaction: GALNT9 → MUC15 (reaction)
  • Reactome Reaction: MUC1 → GALNT9 (reaction)
  • Reactome Reaction: MUC5AC → GALNT8 (reaction)
  • Reactome Reaction: GALNT14 → MUC21 (reaction)
  • Reactome Reaction: GALNT10 → MUC16 (reaction)
  • Reactome Reaction: MUC5B → GALNT12 (reaction)
  • Reactome Reaction: GALNT1 → MUC12 (reaction)
  • Reactome Reaction: MUC5AC → C1GALT1C1 (reaction)
  • Reactome Reaction: MUC3A → GALNT7 (reaction)
  • Reactome Reaction: GALNT11 → MUC20 (reaction)
  • Reactome Reaction: GALNT8 → MUC19 (reaction)
  • Reactome Reaction: GALNT7 → MUC20 (reaction)
  • Reactome Reaction: GALNT15 → MUC3B (reaction)
  • Reactome Reaction: MUC1 → GALNT15 (reaction)
  • Reactome Reaction: GALNT7 → MUC7 (reaction)
  • Reactome Reaction: GALNT10 → MUC17 (reaction)
  • Reactome Reaction: MUC5B → GALNT13 (reaction)
  • Reactome Reaction: GALNT11 → MUC13 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC6 (reaction)
  • Reactome Reaction: GALNT2 → MUC6 (reaction)
  • Reactome Reaction: MUC5AC → GALNT12 (reaction)
  • Reactome Reaction: GALNT1 → MUC4 (reaction)
  • Reactome Reaction: GALNT10 → MUC3B (reaction)
  • Reactome Reaction: GALNT3 → MUC6 (reaction)
  • Reactome Reaction: MUC5B → GALNT11 (reaction)
  • Reactome Reaction: GALNT3 → MUC21 (reaction)
  • Reactome Reaction: GALNT7 → MUC15 (reaction)
  • Reactome Reaction: MUC3A → GALNT11 (reaction)
  • Reactome Reaction: GALNT10 → MUC15 (reaction)
  • Reactome Reaction: GALNT12 → MUC12 (reaction)
  • Reactome Reaction: GALNT7 → MUC6 (reaction)
  • Reactome Reaction: GALNT13 → MUC6 (reaction)
  • Reactome Reaction: GALNT2 → MUC21 (reaction)
  • Reactome Reaction: GALNT12 → MUC6 (reaction)
  • Reactome Reaction: GALNT4 → MUC21 (reaction)
  • Reactome Reaction: GALNT6 → MUC20 (reaction)
  • Reactome Reaction: GALNT9 → MUC12 (reaction)
  • Reactome Reaction: MUC1 → GALNT4 (reaction)
  • Reactome Reaction: GALNT8 → MUC7 (reaction)
  • Reactome Reaction: GALNT13 → MUC16 (reaction)
  • Reactome Reaction: MUC3A → GALNT10 (reaction)
  • Reactome Reaction: MUC5B → GALNT5 (reaction)
  • Reactome Reaction: GALNT11 → MUC12 (reaction)
  • Reactome Reaction: GALNT5 → MUC4 (reaction)
  • Reactome Reaction: GALNT12 → MUC13 (reaction)
  • Reactome Reaction: GALNT5 → MUC7 (reaction)
  • Reactome Reaction: GALNT14 → MUC12 (reaction)
  • Reactome Reaction: GALNT1 → MUC6 (reaction)
  • Reactome Reaction: GALNT15 → MUC19 (reaction)
  • Reactome Reaction: GALNT4 → MUC13 (reaction)
  • Reactome Reaction: MUC2 → GALNT13 (reaction)
  • Reactome Reaction: GALNT14 → MUC20 (reaction)
  • Reactome Reaction: GALNT13 → MUC12 (reaction)
  • Reactome Reaction: MUC5B → GALNT2 (reaction)
  • Reactome Reaction: GALNT11 → MUC17 (reaction)
  • Reactome Reaction: GALNT12 → MUC20 (reaction)
  • Reactome Reaction: C1GALT1C1 → MUC20 (reaction)
  • Reactome Reaction: GALNT15 → MUC16 (reaction)
  • Reactome Reaction: GALNT4 → MUC12 (reaction)
  • Reactome Reaction: GALNT2 → MUC19 (reaction)
  • Reactome Reaction: GALNT3 → MUC3B (reaction)
  • Reactome Reaction: MUC1 → GALNT14 (reaction)
  • Reactome Reaction: GALNT14 → MUCL1 (reaction)
  • Reactome Reaction: GALNT2 → MUC17 (reaction)
  • Reactome Reaction: MUC5B → GALNT3 (reaction)
  • Reactome Reaction: GALNT8 → MUC15 (reaction)
  • Reactome Reaction: GALNT15 → MUC15 (reaction)
  • Reactome Reaction: GALNT8 → MUC13 (reaction)
  • Reactome Reaction: MUC5AC → GALNT6 (reaction)
  • Reactome Reaction: MUC1 → C1GALT1C1 (reaction)
  • Reactome Reaction: MUC2 → GALNT8 (reaction)
  • Reactome Reaction: MUC5AC → GALNT11 (reaction)
  • Reactome Reaction: MUC3A → GALNT5 (reaction)
  • Reactome Reaction: GALNT7 → MUC12 (reaction)
  • Reactome Reaction: GALNT14 → MUC7 (reaction)
  • Reactome Reaction: MUC5AC → GALNT1 (reaction)
  • Reactome Reaction: GALNT3 → MUC15 (reaction)
In total, 288 gene pairs are associated to this article in curated databases