Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202122753-202152434)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL5 ▸ BCL6 ▸ BCL9 ▸ BCL3 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK15 ▸ MAPK13 ▸ MAPK4 ▸ MAPK10 ▸ MAPK14 ▸ MAPK6 ▸ MAPK11 ▸
MAPK7 ▸ MAPK12 ▸ MAPK9 ▸ MAPK8 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN2 ▸ CAPN11 ▸ CAPN15 ▸ CAPN6 ▸ CAPN3 ▸
IL18 ▸ CAPN9 ▸ CAPN12 ▸ CAPN14 ▸ FADD ▸ CAPN8 ▸ CAPN5 ▸
CAPN7 ▸ CAPN13 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP2 ▸
MMP9 ▸ MMP14 ▸ MMP3 ▸ MMP12 ▸ MMP11 ▸ MMP21 ▸ MMP10 ▸
MMP19 ▸ MMP8 ▸ MMP20 ▸ MMP16 ▸ CDKN1A ▸ MMP27 ▸ NLRP3 ▸
MMP28 ▸ MMP7 ▸ MMP17 ▸ MMP25 ▸ MMP15 ▸ MMP24 ▸ MMP26 ▸
MMP1 ▸ MMP13 ▸ CASP9 ▸ JUN ▸ PDCD5 ▸ PDCD11 ▸ RNF19A ▸
CASP12 ▸ CFLAR ▸ PDCD7 ▸ PDCD6 ▸ PDCD4 ▸ PDCD2 ▸ PDCD1 ▸
PDCD10 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ CASP2 ▸ ANXA5 ▸
INS ▸ PCBD1 ▸ AHSA1 ▸ MPZ ▸ TGFB1 ▸ HLA-DRB1 ▸ CASP6 ▸
NLRC4 ▸ CASP7 ▸ PI3 ▸ CASP16 ▸ EPO ▸ CASP5 ▸ PIK3R1 ▸
CASP10 ▸ CASP4 ▸ CASP14 ▸ PIK3CA ▸ TNFRSF1A ▸ DDIT3 ▸ PRKCD ▸
DISC1 ▸ PRDX2 ▸ DISC2 ▸ TAT ▸ DFFA ▸ NOS2 ▸ IL6 ▸
GRAP2 ▸ GSK3B ▸ MYLIP ▸ PCNA ▸ CRK ▸ BIRC2 ▸ CTSB ▸
EGF ▸ IL4 ▸ SOD1 ▸ CAST ▸ VEGFA ▸ EIF2AK2 ▸ IL8 ▸
NOS1 ▸ IRF1 ▸ CTNNB1 ▸ NGF ▸ PTGS2 ▸ BID ▸ PAK2 ▸
DFFB ▸ LEP ▸ DNASE1 ▸ APP ▸ ABL1 ▸ ROCK1 ▸ P2RX7 ▸
HGF ▸ DNASE2 ▸ ALPI ▸ MYC ▸ MAP3K1 ▸ CAT ▸ IL16 ▸
BCR ▸ BDNF ▸ RIPK1 ▸ APEH ▸ TCF4 ▸ IFNB1 ▸ FOS ▸
SOD2 ▸ CDK2 ▸ IFI27 ▸ NFKBIA ▸ MAP2K1 ▸ CSF2 ▸ TCF25 ▸
UPK3B ▸ IL10 ▸ TCF19 ▸ HDAC2 ▸ TCF3 ▸ CA2 ▸ TCF21 ▸
NOX1 ▸ NOS3 ▸ TLR2 ▸ CTSD ▸ TCF20 ▸ TCF15 ▸ TCF7 ▸
IL2 ▸ NOD2 ▸ HTRA2 ▸ TCF23 ▸ TCF12 ▸ RAC1 ▸ TCF24 ▸
BMP1 ▸ HDAC1 ▸ CD8A ▸ LMNB1 ▸ POLDIP2 ▸ ATP5O ▸ SOD3 ▸
BIRC7 ▸ GAL ▸ NOX4 ▸ STAT1 ▸ ARSK ▸ ADCYAP1 ▸ CSF3 ▸
BAD ▸ FGF2 ▸ TLR4 ▸ PRKDC ▸ TLR3 ▸ ITIH4 ▸ BIRC3 ▸
APOB ▸ AIM2 ▸ MAGT1 ▸ HSPA5 ▸ BMP4 ▸ CDC73 ▸ NLRP1 ▸
IL5 ▸ GZMB ▸ NOX5 ▸ CARD8 ▸ BMP10 ▸ SNAP25 ▸ HPR ▸
HSPB1 ▸ NOX3 ▸ PDLIM7 ▸ MST1 ▸ IL3 ▸ PPP2R1A ▸ RB1 ▸
ENDOG ▸ AGTR1 ▸ BMP2 ▸ IL33 ▸ TRAF6 ▸ TLR5 ▸ LEO1 ▸
NOD1 ▸ HMGB1 ▸ KRT18 ▸ IL15 ▸ BMP3 ▸ PPP2CA ▸ BMP6 ▸
SMPD2 ▸ RIPK2 ▸ BMP7 ▸ TLR7 ▸ PML ▸ WDR61 ▸ IL11 ▸
PPP2R2B ▸ CTR9 ▸ PAF1 ▸ BMP5 ▸ BMP15 ▸ STAT3 ▸ CD79A ▸
CDK5 ▸ PPARA ▸ TLR1 ▸ RIPK3 ▸ TXN ▸ GP6 ▸ GP9 ▸
CDH1 ▸ IL24 ▸ SYK ▸ CCDC88A ▸ IL20 ▸ PTX3 ▸ ICAM1 ▸
WAS ▸ JAK2 ▸ EGFR ▸ CREB5 ▸ LPA ▸ ANXA1 ▸ PLCG1 ▸
GP5 ▸ PRNP ▸ APC ▸ TNFRSF1B ▸ EIF2S1 ▸ CXCL9 ▸ CREB1 ▸
GSN ▸ PTX4 ▸ RAD51 ▸ NPS ▸ CSE ▸ PGP ▸ LMNB2 ▸
BIRC6 ▸ IGF2 ▸ RBBP4 ▸ MAP2K2 ▸ TLR8 ▸ RBBP7 ▸ HIF1A ▸
IL21 ▸ MET ▸ CDC6 ▸ HTT ▸ BOC ▸ CREB3 ▸ CD4 ▸
TLR10 ▸ GP2 ▸ ABCC6 ▸ IL27 ▸ RRAS ▸ CCL2 ▸ MUC7 ▸
RENBP ▸ MUC17 ▸ CCND1 ▸ GATA1 ▸ MUC16 ▸ MUC12 ▸ TLR9 ▸
IL31 ▸ TRAF1 ▸ BRCA1 ▸ ACTL6A ▸ HSPD1 ▸ MUC1 ▸ PLD1 ▸
CARD11 ▸ MUC20 ▸ SMARCB1 ▸ IRF3 ▸ MUC4 ▸ SMARCD1 ▸ IL34 ▸
MUC21 ▸ IL25 ▸ ARID1A ▸ MSC ▸ ACHE ▸ CDK8 ▸ FOXO3 ▸
CARD6 ▸ CARD9 ▸ IL37 ▸ SMARCA4 ▸ MDM2 ▸ MUC2 ▸ IKBKB ▸
MEFV ▸ SMARCA2 ▸ MUC22 ▸ MUC8 ▸ SMPD1 ▸ IL32 ▸ CDA ▸
IL26 ▸ MUC19 ▸ IL22 ▸ SMARCE1 ▸ IL9 ▸ PPARG ▸ MUC6 ▸
BECN1 ▸ RAF1 ▸ MUC15 ▸ SMARCC2 ▸ IL7 ▸ ROCK2 ▸ SMARCD2 ▸
KDR ▸ SMARCC1 ▸ UCN ▸ MUC13 ▸ HMOX1 ▸ TLR6 ▸ STX1A ▸
ANGPT2 ▸ LYN ▸ PAK1 ▸ IL13 ▸ IL19 ▸ SYT1 ▸ CD79B ▸
TOP1 ▸ CEP72 ▸ IGF1R ▸ TARDBP ▸ PRKAR2A ▸ MIF ▸ CEP152 ▸
CEP63 ▸ GRB14 ▸ ATG5 ▸ GUCY2D ▸ RASA1 ▸ GRB10 ▸ CARD14 ▸
HIP1 ▸ ARC ▸ BCL2L12 ▸ GRB7 ▸ CEP41 ▸ CEP55 ▸ PXN ▸
SETBP1 ▸ NUP62 ▸ BIRC5 ▸ EPX ▸ NPM1 ▸ SEC14L2 ▸ IKBKG ▸
HSP90AA1 ▸ ELAVL1 ▸ PTEN ▸ CEP95 ▸ CARD18 ▸ GRK7 ▸ CEP85 ▸
CEP89 ▸ PRKCG ▸ CEP290 ▸ CEP70 ▸ SLCO6A1 ▸ CEP78 ▸ TRAF3 ▸
HSF1 ▸ CEP128 ▸ MAP2K3 ▸ IL1RN ▸ MAP2K7 ▸ CARD10 ▸ WNT1 ▸
SKP1 ▸ PRKAR1B ▸ CEP350 ▸ NUP214 ▸ CEP76 ▸ PTK2 ▸ SLC9A1 ▸
LYPLA1 ▸ HUNK ▸ ALK ▸ VDAC1 ▸ CEP19 ▸ DST ▸ HIST2H2BE ▸
CCR7 ▸ GRK6 ▸ PLOD2 ▸ CUL1 ▸ GDNF ▸ CDK4 ▸ ARSA ▸
CEP170 ▸ BACE1 ▸ EHMT1 ▸ PTBP1 ▸ CD40 ▸ PRKAR1A ▸ CEP68 ▸
CEP57 ▸ CEP104 ▸ VCP ▸ PEA15 ▸ PIDD ▸ GRK5 ▸ PSMD10 ▸
PRKACG ▸ IRF5 ▸ BIRC8 ▸ ANGPT1 ▸ TRAF2 ▸ LAT ▸ PLD2 ▸
PRKACB ▸ SETD2 ▸ PANX1 ▸ SOAT1 ▸ CARD16 ▸ VIMP ▸ GRK1 ▸
TNFRSF10A ▸ NUP210 ▸ VIM ▸ CEP192 ▸ ME2 ▸ FOXO1 ▸ CEP44 ▸
NUP153 ▸ CARD17 ▸ CEP120 ▸ PTHLH ▸ TCHP ▸ CEP164 ▸ DERL1 ▸
MEPE ▸ CEP112 ▸ CD47 ▸ ADIPOQ ▸ PRKAR2B ▸ GRB2 ▸ GRK4 ▸
SLC17A5 ▸ PRKCA ▸ MPST ▸ PSEN1 ▸ E2F1 ▸ DES ▸ CALM3 ▸
CEP97 ▸ IRF2 ▸ MAP2K6 ▸ CEP250 ▸ MAP2K4 ▸ CEP135 ▸ NPY6R ▸
SP1 ▸ MAP2K5 ▸ H2AFX ▸ IRF4 ▸ ALB ▸ TAC4 ▸ NUAK1 ▸
NLRP5 ▸ HIPK2 ▸ PAN3 ▸ RAD17 ▸ RUNX3 ▸ PRG4 ▸ XAF1 ▸
NANOS2 ▸ CCR2 ▸ GPX3 ▸ KLF4 ▸ DIDO1 ▸ VDAC2 ▸ PLK1 ▸
NANOG ▸ AIP ▸ ACSM3 ▸ MICE ▸ KLKB1 ▸ MED25 ▸ IFI44 ▸
ACIN1 ▸ CISH ▸ MED8 ▸ ANP32A ▸ RARA ▸ TYR ▸ PGF ▸
MED24 ▸ SERPINA1 ▸ CA8 ▸ ATG3 ▸ PLD4 ▸ ACAD8 ▸ MTA2 ▸
PRKAB2 ▸ NR0B1 ▸ SUB1 ▸ RIPK4 ▸ FAM168B ▸ PPP1R3A ▸ MED12 ▸
ATF5 ▸ CCL19 ▸ TSC22D3 ▸ APOE ▸ PLD5 ▸ TAC1 ▸ PMEL ▸
EDNRA ▸ MED23 ▸ CDK10 ▸ COP ▸ ID3 ▸ PPT1 ▸ IRF9 ▸
MTOR ▸ SPP1 ▸ ATM ▸ APEX1 ▸ CCR10 ▸ HDAC4 ▸ RAC3 ▸
TIMP3 ▸ SAA1 ▸ IGFBP3 ▸ TRAF4 ▸ CCNC ▸ CDK13 ▸ IFNA2 ▸
CXCL17 ▸ CCNH ▸ PTPN11 ▸ PRKAB1 ▸ CALB1 ▸ RBL2 ▸ PAN2 ▸
SATB1 ▸ MED6 ▸ MED17 ▸ GLI1 ▸ THBS1 ▸ NTF4 ▸ IRF8 ▸
ADH5 ▸ RAD21 ▸ RANBP2 ▸ CDK20 ▸ IAPP ▸ PSMB9 ▸ GSTT1 ▸
NPPA ▸ PC ▸ EIF4G2 ▸ HDAC6 ▸ LGALS1 ▸ GNRH1 ▸ SLPI ▸
MME ▸ CFL1 ▸ HMGCR ▸ STSP1 ▸ XRCC6 ▸ CD8B ▸ MED1 ▸
TNFRSF10B ▸ CTNNBL1 ▸ ING1 ▸ MED4 ▸ CYR61 ▸ SHC1 ▸ STX2 ▸
CRYAB ▸ SMAD3 ▸ CDK6 ▸ PRKAG2 ▸ MAP2 ▸ TRA ▸ RAC2 ▸
CDK19 ▸ NAIP ▸ UCP2 ▸ JAK1 ▸ NTF3 ▸ FUT1 ▸ RHO ▸
ADM ▸ TRAF5 ▸ EMP3 ▸ HTRA4 ▸ GHSR ▸ EMP2 ▸ E2F2 ▸
DHCR24 ▸ CDK12 ▸ DAPK2 ▸ PSENEN ▸ CPOX ▸ GYS1 ▸ PRKAA2 ▸
IARS ▸ IDO1 ▸ CCR5 ▸ BNIP3 ▸ PTCH1 ▸ CDK3 ▸ QRICH1 ▸
GYS2 ▸ MLYCD ▸ FAF1 ▸ SREBF1 ▸ MT4 ▸ PDGFB ▸ SMAD7 ▸
TRAF7 ▸ APOBEC3D ▸ PAEP ▸ NAB2 ▸ CAPNS1 ▸ IRS1 ▸ TGM2 ▸
CXCL13 ▸ KMT2A ▸ MT3 ▸ ETS2 ▸ CDCA5 ▸ RAD18 ▸ TGFB3 ▸
STC1 ▸ LRP1 ▸ MTA1 ▸ PNPLA2 ▸ GPI ▸ DAP3 ▸ GRP ▸
E2F3 ▸ NLRP7 ▸ CFTR ▸ SERPINF1 ▸ FOXP3 ▸ EEF1A2 ▸ TET1 ▸
TFAP2A ▸ GJA1 ▸ DNAJC5 ▸ CCR8 ▸ EMP1 ▸ LRRC59 ▸ BLM ▸
FHIT ▸ TAC3 ▸ ETS1 ▸ SERPINB9 ▸ DAXX ▸ PLD3 ▸ BAG3 ▸
CDK14 ▸ CENPK ▸ ANG ▸ BCAP31 ▸ HCLS1 ▸ SERP2 ▸ CDK18 ▸
SEPT4 ▸ EIF4G3 ▸ NTN1 ▸ ZGLP1 ▸ EIF4G1 ▸ IFIH1 ▸ CTNND1 ▸
APIP ▸ MAP3K7 ▸ CDK17 ▸ RAD50 ▸ CPA1 ▸ MED26 ▸ KLK3 ▸
MED15 ▸ CCK ▸ QRICH2 ▸ CD2 ▸ CTRL ▸ CDK1 ▸ DLG1 ▸
SIVA1 ▸ RAD1 ▸ MED21 ▸ PRG3 ▸ NUP43 ▸ JAK3 ▸ PRKAA1 ▸
PIN1 ▸ ODC1 ▸ SDS ▸ CTSL ▸ RAD52 ▸ HTRA3 ▸ GNA11 ▸
SREBF2 ▸ MST1R ▸ PARG ▸ HTRA1 ▸ PRKAG1 ▸ NACA ▸ HRK ▸
S100A12 ▸ TET3 ▸ CDK15 ▸ MED13 ▸ CHUK ▸ CCR9 ▸ TET2 ▸
TNFSF12 ▸ WNT3A ▸ CALML3 ▸ AFP ▸ CCR1 ▸ DYRK1A ▸ CCR6 ▸
PRG2 ▸ TNFRSF8 ▸ CDK7 ▸ IRF7 ▸ CSF1 ▸ VIP ▸ CALR ▸
RAB5A ▸ NAB1 ▸ GPX1 ▸ CCR3 ▸ CIB1 ▸ ITCH ▸ CDK16 ▸
SMAD4 ▸ CDK9 ▸ C22orf29 ▸ EML2 ▸ SRC ▸ HRD ▸ ATF2 ▸
ERVK-6 ▸ ABCD1 ▸ TMED7 ▸ MTA3 ▸ WNK1 ▸ ANXA6 ▸ MED7 ▸
MED14 ▸ CCR4 ▸ CDC42 ▸ NLRC5 ▸ VDAC3 ▸ PLD6 ▸ IL1R2 ▸
TNFSF14 ▸ STK24 ▸ ACTA2 ▸ CASP8AP2 ▸ COL6A2 ▸ TRIM28 ▸ TNFAIP3 ▸
UBE2D1 ▸ TOPORS ▸ BNIP3L ▸ IRS4 ▸ PLEC ▸ COL3A1 ▸ EIF3S10 ▸
UBB ▸ COL4A5 ▸ MSN ▸ ATG4D ▸ AR ▸ COPS6 ▸ KRR1 ▸
SQSTM1 ▸ CD3E ▸ CD3G ▸ COL4A4 ▸ COL6A3 ▸ UBC ▸ CUL3 ▸
TUBA1A ▸ PLIN4 ▸ COL5A2 ▸ PIAS1 ▸ CLIP3 ▸ COL11A1 ▸ ITGAV ▸
COL4A6 ▸ GRIA1 ▸ SYF2 ▸ MAP1LC3B ▸ CD14 ▸ PRKCI ▸ ATN1 ▸
TUBB ▸ TRIM25 ▸ PIDD1 ▸ DNAJC7 ▸ YES1 ▸ ITGB3 ▸ RNF135 ▸
RPS27L ▸ IL1R1 ▸ RALBP1 ▸ TICAM2 ▸ SPARC ▸ TNFRSF25 ▸ PYCARD ▸
CD247 ▸ COL4A1 ▸ HNRNPH2 ▸ TFCP2 ▸ EIF4A1 ▸ ARHGDIA ▸ PLA2G4B ▸
CD3D ▸ IQGAP1 ▸ PICALM ▸ MAP4K4 ▸ DEDD2 ▸ PTPN6 ▸ CDK11A ▸
COL1A1 ▸ RAB10 ▸ TUBA1C ▸ MAP1LC3A ▸ COL6A1 ▸ EZR ▸ MAPT ▸
EDA2R ▸ PCYT1A ▸ MALT1 ▸ ITGB1 ▸ RNF34 ▸ USP2 ▸ PDIA6 ▸
PTPN13 ▸ COL11A2 ▸ FIS1 ▸ CDK11B ▸ COL7A1 ▸ RALGDS ▸ RPS27 ▸
MAP3K14 ▸ COL2A1 ▸ NUCB1 ▸ CHD3 ▸ PARK7 ▸ MYO9A ▸ BFAR ▸
SORBS1 ▸ CLTC ▸ UBR5 ▸ IFT57 ▸ PARK2 ▸ ITGA2 ▸ DDX28 ▸
NUCB2 ▸ EP300 ▸ NEFH ▸ ACTG2 ▸ HIST1H4A ▸ UBE2L3 ▸ KARS ▸
COL4A3 ▸ NR1H4 ▸ NOL3 ▸ CRADD ▸ NCL ▸ COL5A1 ▸ LY96 ▸
KHDRBS1 ▸ ATAD3A ▸ OTUD7B ▸ USP54 ▸ COL1A2 ▸
Data information
Please see the Gene Interactions Track Manual.