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EPHB2 — SPHK1
Text-mined interactions from Literome
Blaukat et al., Biol Chem 2001
:
Overexpression of
sphingosine kinase did not additionally
increase the bradykinin induced
ERK/MAP kinase activity, indicating a permissive rather than activating role of sphingosine 1-phosphate in B2 receptor mediated mitogenic signaling
Nava et al., Exp Cell Res 2002
(Adenocarcinoma...) :
While both ERK and Akt have been implicated in MCF-7 cell growth,
SPHK1 stimulated
ERK1/2 but had no effect on Akt
Monick et al., Am J Respir Cell Mol Biol 2004
(Respiratory Syncytial Virus Infections) :
S1P activated Akt and
ERK within minutes, and inhibition of
sphingosine kinase blocked RSV induced ERK and Akt activation, leading to accelerated cell death after viral infection
Koda et al., Biochim Biophys Acta 2005
:
The overexpression of wild-type
SPHK1 , but not dominant negative SPHK1,
resulted in high basal levels of
ERK1/2 phosphorylation and stimulated granulocytic differentiation in HL60 cells
Johnstone et al., Placenta 2005
:
Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase, Akt,
ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % )
inhibited the EGF stimulated increase in
SPHK-1 activity
Bu et al., FASEB J 2006
:
Additional data revealed a specific role of dhS1P, and not S1P, as a mediator of
SphK1 dependent activation of
ERK1/2 and up-regulation of MMP1
Radeff-Huang et al., J Biol Chem 2007
(Brain Neoplasms...) :
ERK activation was also required for TNF-alpha stimulated DNA synthesis but likewise TNF-alpha induced ERK activation was not blocked by inhibition of
SphK
Murakami et al., J Neurochem 2007
(Multiple Endocrine Neoplasia Type 2a...) :
Furthermore, we demonstrated that
ERK1/2 and PI3 kinase are
involved in GDNF induced
SPHK1 transcription by using specific inhibitors
Serrano-Sanchez et al., Endocrinology 2008
:
Inhibition of PKC and
ERK reduced
SphK1/2 activity
Ramachandran et al., FEBS Lett 2010
(Stomach Neoplasms) :
Lysophosphatidic acid stimulates gastric cancer cell proliferation via
ERK1 dependent upregulation of
sphingosine kinase 1 transcription ... Although LPA activates numerous signaling pathways downstream of its receptors, including extracellular-signal regulated kinase 1/2, p38, JNK, and Akt, and the transactivation of the epidermal growth factor receptor, pharmacological and molecular approaches demonstrated that only activation of
ERK1 , in addition to the CCAAT/enhancer binding protein ß transcription factor, is
involved in transcriptional upregulation of
SphK1 by LPA
Kharel et al., Biochem J 2011
:
However,
SphK1 inhibition did
diminish EGF ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B )
/ERK ( extracellular-signal regulated kinase ) phosphorylation
Zhang et al., Biochem Biophys Res Commun 2013
(Carcinoma, Hepatocellular...) :
Given the up-regulated expression of
SphK1 in
response to the silence of N-ras and other interactions between
Ras/ERK and SphK1, it was speculated that combined inhibition of Ras/ERK and SphK1 would create enhanced antitumor effects