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EPHB2 — TNFSF10
Text-mined interactions from Literome
Tran et al., J Biol Chem 2001
:
Activation of the FasR, TNF-R1, and
TRAIL-R , respectively, rapidly
induced subsequent
ERK1/2 activation, an event independent from caspase activity
Milani et al., J Neurochem 2003
(Neuroblastoma) :
TRAIL rapidly ( from 20 min )
induced the phosphorylation of Akt and
ERK , but not of c-Jun NH2-terminal kinase (JNK)
Mezosi et al., J Clin Endocrinol Metab 2004
:
A MAPK kinase inhibitor ( U0126 ) could enhance the cytokine induced sensitization of thyroid cells to TRAIL, reinforcing the inhibitory
role of
Erk on
TRAIL signaling
Zhang et al., Cancer Biol Ther 2004
(Colonic Neoplasms) :
TRAIL mediated activation of
ERK occurred in both cell lines
Secchiero et al., Cell Mol Life Sci 2004
:
Western blot analysis consistently showed that
TRAIL induced a significant activation of
ERK1/2 , and a much weaker phosphorylation of Akt, while it did not affect the p38/MAPK pathway
Drosopoulos et al., J Biol Chem 2005
(Cell Transformation, Neoplastic...) :
We also report a prolonged MEK dependent activation of
ERK1/2 and increased c-FOS expression
induced by
TRAIL in this system
Li et al., Int J Mol Med 2006
(Ovarian Neoplasms) :
Simultaneously, silencing of hPEBP4 in CaoV-3 cells enhances
TRAIL induced
ERK and JNK activation
Lee et al., Biochem Biophys Res Commun 2006
(Breast Neoplasms) :
TRAIL mediated activation of
ERK and JNK were also observed in parent MDA-231 cells but not in MDA-231/TR cells
Rieger et al., Cell Physiol Biochem 2007
(Glioma) :
Apo2L.0 induced the phosphorylation of
ERK1/2 , but not of Akt
Vilimanovich et al., Cell Mol Life Sci 2008
(Brain Neoplasms...) :
In addition, siRNA inhibition of c-FLIP expression eliminates
TRAIL induced
ERK1/2 activation and proliferation ... Furthermore, overexpression of c-FLIP ( L ) potentiates
TRAIL induced
ERK1/2 activation and proliferation of resistant glioma cells ... Our results have shown for the first time that
TRAIL induced
ERK1/2 activation and proliferation of TRAIL-resistant human glioma cells is dependent upon the expression of the long form of the caspase-8 inhibitor c-FLIP ( L )
Sung et al., J Biol Chem 2010
(Colonic Neoplasms) :
ERK1/2 ( but not p38 MAPK or JNK ) activation was also
required for gossypol induced
TRAIL receptor induction ; gene silencing of ERK abolished both DR5 induction and potentiation of apoptosis by TRAIL