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IL6 — PRNP

Text-mined interactions from Literome

Veerhuis et al., Brain Res 2002 (Prion Diseases) : Since microglial COX-2 expression and PGE ( 2 ) synthesis are increased in human and experimental prion diseases, we investigated the effects of the NSAIDs indomethacin and BF389, an experimental COX-2 selective inhibitor, on the PrP105-132 induced microglial IL-6 and TNF-alpha synthesis in vitro ... We conclude that, unlike IL-1beta induced IL-6 synthesis in astrocytes, the PrP induced IL-6 synthesis in human adult microglia is not PGE2 mediated
Isaacs et al., J Neuropathol Exp Neurol 2006 : The residue 129 polymorphism was also associated with distinct patterns of cytokine response : PrP 128-141 [ 129M ] inducing IL-4 and IL-6 production, which was not seen in response to PrP 128-141 [ 129V ]