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Text-mined interactions from Literome
Chiang et al., J Clin Endocrinol Metab 2000
:
Furthermore, our data suggest that the effects of hCG and GnRH on
ERalpha and ERbeta expression in hGLCs are
mediated in part by activation of
PKA and PKC signaling pathways, respectively
Jessop et al., J Bone Miner Res 2001
:
Activation of ERK-1 and the phosphorylation of
ER-alpha , by both estrogen and strain, were
prevented by the MAP kinase kinase ( MEK ) inhibitor U0126 and the
protein kinase A (PKA) inhibitor ( PKI )
Tsai et al., Endocrinology 2004
:
These data suggest a mechanism of
ERalpha transcriptional
activation by
PKA that is distinct from E2 activation and that may contribute to the synergistic transcriptional activation of ERalpha by ligand dependent and PKA dependent pathways
Hsieh et al., Am J Pathol 2007
(Hemorrhage...) :
We found that suppression of GPR30 but not
ER-alpha prevented E2-BSA- or E2-induced
PKA activation and Bcl-2 expression
Zwart et al., EMBO J 2007
:
In a previous study, we showed that
protein kinase A (PKA) mediated phosphorylation of serine 305 ( S305 ) of
ERalpha results in resistance to tamoxifen ... This intermolecular reorientation as a result of
PKA mediated phosphorylation of
ERalpha-S305 and tamoxifen binding provides a unique model for resistance to the anticancer drug tamoxifen
Etique et al., Int J Oncol 2007
(Breast Neoplasms) :
Using PKA inhibitor ( H89 ), the study of phospho-CREB by Western blot and transfection experiments with a CRE-reporter construct demonstrated that
PKA was
involved in ethanol induced transcription of
ERalpha target genes
Yum et al., Mol Cells 2009
:
In the present study, we examined the
effects of
PKA activation on the ability of FoxH1 to represses
ERalpha transcriptional activity ... These results suggest that
PKA can negatively
regulate ERalpha , at least in part, through FoxH1