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CCL20 — TNF
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
NFKB1/RELA
→
Complex of CXCL8-IFNB1-CCL20-TNF-CCL5
(activation)
Text-mined interactions from Literome
Matsui et al., Clin Exp Immunol 2001
(Arthritis, Rheumatoid) :
Cultured synovial fibroblasts derived from either RA or OA patients were capable of producing
MIP-3 alpha in
response to IL-1 beta and
TNFalpha in vitro
Tohyama et al., J Dermatol Sci 2001
:
Based on these results, we postulate that
MIP-3alpha produced by keratinocytes in the spinous layer in
response to
TNF-alpha stimulation is a key chemokine responsible for the epidermal recruitment of Langerhans cells
Sugita et al., J Immunol 2002
:
Induction of
macrophage-inflammatory protein-3alpha gene expression by
TNF dependent NF-kappaB activation ...
MIP-3alpha transcription was
stimulated by
TNF , and this stimulation was inhibited by an NF-kappaB inhibitor, I-kappaBalpha superrepressor
Abiko et al., Arch Oral Biol 2003
(Carcinoma, Squamous Cell...) :
The expression of
MIP-3alpha was upregulated by infection with Actinobacillus actinomycetemcomitans and by
stimulation with lipopolysaccharide and
TNF-alpha
Ruth et al., Lab Invest 2003
(Arthritis, Rheumatoid...) :
IL-1beta, IL-18, and
TNF-alpha stimulated RA fibroblast
MIP-3alpha production at 48 hours of incubation in vitro
Starner et al., Am J Respir Cell Mol Biol 2003
:
Expression of
CCL20 transcripts were significantly
induced by interleukin (IL)-1beta and
tumor necrosis factor-alpha , and inhibited by dexamethasone
Veckman et al., J Leukoc Biol 2003
:
CCL19 and
CCL20 mRNA expression was
up-regulated by IL-1beta or
tumor necrosis factor alpha (TNF-alpha) , and in addition, IFN-alpha together with TNF-alpha further enhanced CCL19 gene expression
Kaser et al., J Clin Immunol 2004
(Colitis, Ulcerative...) :
TNF-alpha increased and anti-TNF-alpha decreased
CCL20 release in healthy control CEC but not in involved IBD colonic specimens
Kawano et al., Fertil Steril 2004
(Infertility, Female) :
The
effects of interleukin (IL)-1alpha, IL-1 receptor antagonist (RA), and
tumor necrosis factor (TNF)-alpha on the secretion of
MIP-3alpha by primary cultured granulosa-lutein cells and an immortalized granulosa cell line ( GC1a ) were investigated ... Our data suggest that
MIP-3alpha was present in follicular fluid and correlated with oocyte maturation, and was
regulated by IL-1alpha and
TNF-alpha
Crane-Godreau et al., Infect Immun 2005
:
In response to LPS, LTA, and Pam ( 3 ) Cys ( EMC Microcollection GmbH, Tubingen, Germany ),
CCL20 levels increased ( 4- to 10-fold ) while PAMPs
caused increased
TNF-alpha ( 1- to 4-fold ) in the medium collected after 24 h of incubation
Lee et al., Exp Mol Med 2005
:
A pharmacologic study also revealed that multiple signaling pathways are differentially involved in CCL20 production by DFO, while some of those pathways are not involved in
TNF-alpha induced
CCL20 production
Hosokawa et al., Clin Exp Immunol 2005
:
Here, we report that interleukin-1 beta (IL-1beta),
tumour necrosis factor-alpha (TNF-alpha) and Escherichia coli lipopolysaccharide (LPS) can significantly
induce the production of
CCL20 by HGF ... We found that
TNF-alpha and E. coli LPS
enhanced the production of
CCL20 by HGF treated with IL-1beta ... Moreover, we demonstrated that nuclear factor-kappaB (NF-kappaB), p38 mitogen activated protein kinase ( MAPK ) and extracellular signal regulated kinases ( ERK ) play an important role in mediating the production of
CCL20 induced by IL-1beta and
TNF-alpha
Hasan et al., J Immunol 2006
(Melanoma) :
CCL20 production was
up-regulated by IL-1alpha and
TNF-alpha in all cell lines tested, and in human metastatic melanoma cells
Choi et al., World J Gastroenterol 2006
:
DA-9601, a standardized extract of Artemisia asiatica, blocks
TNF-alpha induced IL-8 and
CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells ... Treatment of AGS cells with DA-9601 reduced
TNF-alpha induced IL-8 and
CCL20 promoter activities, as well as their gene expression and protein release
Marcet et al., J Cell Physiol 2007
:
Furthermore, UTP had no effect on interleukin-(IL)-8 release and reduced the release of both
CCL20 and IL-8
induced by
TNF-alpha and LPS
Kageyama et al., Rheumatol Int 2007
(Arthritis, Gouty...) :
TNF-alpha induced
MIP-3alpha but not IL-23 production in cultured synovial cells from RA patients
Takahashi et al., Oral Microbiol Immunol 2008
(Pulpitis) :
Moreover,
CCL20 production from pulpal fibroblasts was
increased by stimulation with inetrleukin-1beta and
tumor necrosis factor-alpha
Tanida et al., Cytokine 2009
(Arthritis, Rheumatoid) :
IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of
CCL20 induced by
TNF-alpha was partially attributed to a trace amount of IL-1beta induced by TNF-alpha ... The production of
CCL20 induced by
TNF-alpha and IL-1beta was modified by helper-T-cell derived cytokines
Wang et al., Arch Oral Biol 2009
(Autoimmune Diseases...) :
Collectively,
TNF-alpha dependent activation of the extrinsic apoptotic pathway
leads to upregulation of ICAM-1 and
CCL20 in HSG in vitro
Shibata et al., J Invest Dermatol 2010
(Psoriasis) :
Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the
tumor necrosis factor-alpha induced production of IL-1alpha and
CCL20
Wang et al., Virology journal 2010
(Condylomata Acuminata) :
CCL-20 expression can be
increased by
TNF-a and IL-1a
Kanda et al., Endocrinology 2011
(Psoriasis) :
Visfatin enhanced
TNF-a induced CXC chemokine ligand ( CXCL ) 8, CXCL10, and
CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Kim et al., Exp Dermatol 2011
(Psoriasis) :
We demonstrated that IL-1ß,
TNF-a , and IL-17A significantly
increased CCL20 production from HaCaT cells
Iwamoto et al., Clin Immunol 2013
(Hepatitis, Autoimmune) :
Administering
anti-TNF-a did not prevent splenic T-cell activation, but did
suppress hepatic
CCL20 expression ...
TNF-a stimulation
enhanced CCL20 expression in hepatocytes
Kok et al., Arthritis Rheum 2013
(Arthritis, Experimental...) :
In RASFs, simvastatin suppressed the
tumor necrosis factor a (TNFa) induced production of CYR-61 and
CCL20
Kitagawa et al., Surgery 2013
(Disease Models, Animal...) :
Inhibition of
CCL20 increased serum
tumor necrosis factor (TNF)-a ( 3.3-fold greater than control mice ) and decreased serum interleukin (IL)-1a and IL-6
Son et al., Journal of inflammation (London, England) 2013
:
Finally,
CCL20 and CXCL8 responded synergistically in
response to EGF and
TNF in OVCAR-3 and SKOV-3 cells