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CAT — PTGS2

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Fang et al., J Neurochem 2000 : Induction of cyclooxygenase-2 by overexpression of the human catalase gene in cerebral microvascular endothelial cells
Armstead et al., Anesthesiology 2003 (Brain Injuries) : Indomethacin ( a cyclooxygenase-1 and cyclooxygenase-2 inhibitor ), NS398 ( a cyclooxygenase-2 inhibitor ), and polyethylene glycol superoxide dismutase and catalase ( free radical scavengers ) partially restored impaired mastoparan dilation after FPI in the newborn in a roughly equivalent manner but not in the juvenile ( 3 +/- 1 and 5 +/- 1 vs. 8 +/- 1 and 13 +/- 1 % newborn, 6 +/- 1 and 9 +/- 1 vs. 7 +/- 1 and 10 +/- 1 % juvenile for NS398 pretreatment )
Jang et al., Biochem Biophys Res Commun 2004 : Induction of cyclooxygenase-2 in macrophages by catalase : role of NF-kappaB and PI3K signaling pathways ... Induction of COX-2 by catalase in smooth muscle cells, endothelial cells, and neuronal cells has been previously reported ... In this study, we investigated the effect of catalase on induction of COX-2 in macrophages ... Catalase also induced activation of NF-kappaB, PI3K, ERKs, p38s, or JNKs. Catalase induced COX-2 expression was abrogated by treatment of MG-132 ( a NF-kappaB inhibitor ) or LY294002 ( a PI3K inhibitor ), but not by treatment of PD98059 ( an ERK inhibitor ), SB203580 ( a p38 inhibitor ), or SP600125 ( a JNK inhibitor ) ... Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability ... Together, these results suggest that catalase induces the expression of COX-2 in Raw 264.7 macrophages, and the induction is related with activation of NF-kappaB transcription factor and PI3K signaling pathway
Litvinov et al., Biochimie 2004 : Extracellular catalase induces cyclooxygenase 2 , interleukin 8, and stromelysin genes in primary human chondrocytes
Jang et al., Cell Signal 2005 : Catalase induces COX-2 or iNOS expression in some type of cells, but the mechanism remains unclear ... Here we investigated the effect of catalase on COX-2 and iNOS expression in BV2 microglia and the inductive mechanism associated ... Importantly, catalase induced COX-2 and iNOS expression needed activations of NF-kappaB, PI3K/AKT, and JNKs, which were important for the transcriptional up-regulation of COX-2 and iNOS ... Notably, rapamycin inhibition of p70S6K led to down-regulation of COX-2 and iNOS protein expression, but not steady-state mRNA expression and transcription, induced by catalase , suggesting that p70S6K is involved in increased COX-2 and iNOS mRNA translation by catalase ... These data collectively suggest catalase induced COX-2 and iNOS expression in BV2 microglia is, in part at least, mediated through activation of multiple signaling proteins
Chang et al., Biomaterials 2009 (MAP Kinase Signaling System) : Catalase ( 500 and 1000 U/ml ) and U0126 ( 10 and 20 microm, a MEK inhibitor ) effectively prevented the BisGMA induced ERK activation, PGE ( 2 ) production and COX-2 expression
Chen et al., Biochem Pharmacol 1998 : The expression of mRNA for COX-2 induced by catalase was blocked completely by actinomycin D ( ACT ) or cycloheximide ( CHX ) ... The increase in expression of mRNA for COX-2 induced by catalase may be related to the ability of catalase to stimulate cyclic AMP response element ( CRE ) and NF-IL6 transcription factors, but not nuclear factor kappa B (NF-kappaB), for electrophoretic mobility shift assays ( EMSA ) showed that catalase enhanced nuclear factor binding to cyclic AMP response element and NF-IL6 but not to NF-kappaB