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HSP90AA1 — KCNQ4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gao et al., PloS one 2013
(Hearing Loss, Sensorineural...) :
KCNQ4 surface expression was
restored by
HSP90ß in cells mimicking heterozygous conditions of the DFNA2 patients, even though it was not sufficient to rescue the function of KCNQ4 channels
Gao et al., J Cell Mol Med 2013
:
Most importantly, overexpression of
HSP90ß , a key component of the molecular chaperone network that controls the KCNQ4 biogenesis, significantly
increased cell surface expression of the
KCNQ4 mutants L281S, G296S and G321S