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GAST — ITGAM

Text-mined interactions from Literome

Saetre et al., APMIS 2000 (Bacteremia...) : To elucidate the innate immune responses to group A streptococci (GAS) important in the pathophysiology of sepsis, flow cytometric techniques were applied to study the effects of live and heat inactivated GAS , including their particulate and soluble components, on the expression of leukocyte adhesion molecules CD11b ( Mac-1 ) and CD62L ( L-selectin ), and leukocyte production of reactive oxygen species ( ROS ) in human whole blood ... GAS caused marked time- and concentration dependent increases in CD11b and ROS, while CD62L was downregulated
Weineisen et al., J Immunol 2004 : We conclude that M5 protein interferes with the CD11b/CD18 dependent association between GAS and neutrophils, and thereby blocks subsequent ingestion of the bacteria