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CCL3 — IL6
Text-mined interactions from Literome
Waehre et al., J Am Coll Cardiol 2003
(Coronary Artery Disease) :
Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and
interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly
reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy reduced the spontaneous release of IL-8 and
MIP-1alpha from PBMCs in CAD patients
Ellaban et al., Cell Immunol 2004
(Cecal Diseases...) :
While production of
IL-6 and KC was reduced, secretion of TNF-alpha and
MIP-1alpha was
enhanced in those cells isolated from mice with mild sepsis
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation...) :
H/R ( 3 h/1 h ) significantly
induced KC, MCP-1, macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and
IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha, MCP-1, RANTES,
MIP-1alpha , and MIP-2 ( but not KC ) by RAW264.7 cells
Wu et al., J Gen Virol 2010
(Adenoviridae Infections...) :
The results showed that IL-8 and
IL-6 were
induced 8 h after infection and, by 24 h, levels of IL-8, IL-6,
MIP-1alpha/beta and MCP-1 were all increased
Zhang et al., J Biol Chem 2013
:
In vitro,
IL-6 deficiency or Signal Transducer and Activator of Transcription 3 ( STAT3 ) knockdown in activated macrophage
attenuated the expression of CCL2,
CCL3 , but not CCL5, which resulted in less macrophage migration
Wang et al., Arthritis Rheum 2013
(Intervertebral Disc Degeneration...) :
Tumor necrosis factor a- and
interleukin-1ß dependent induction of
CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
Dudley et al., Am J Reprod Immunol 1995
:
IL-6 had no effect on
MIP-1 alpha production
Dudley et al., J Soc Gynecol Investig 1996
:
Macrophage inflammatory protein-I alpha regulates prostaglandin E2 and
interleukin-6 production by human gestational tissues in vitro
Leng et al., J Immunol 1997
(Leukemia, Monocytic, Acute) :
IL-11 did not similarly regulate monocyte/macrophage production of IL-8 or
macrophage inflammatory protein-1alpha ( MIP-1alpha ) and
IL-6 did not similarly
inhibit IL-12 elaboration
Matsumoto et al., Int Immunol 1998
(Leukemia, Monocytic, Acute) :
Inducible expression of nuclear factor
IL-6 increases endogenous gene expression of
macrophage inflammatory protein-1 alpha , osteopontin and CD14 in a monocytic leukemia cell line ... We demonstrated that inducible expression of
NF-IL6 is able to
increase endogenous gene expression of macrophage inflammatory protein
(MIP)-1 alpha , osteopontin and CD14 in M1 cells