Gene interactions and pathways from curated databases and text-mining

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CCL3 — IL6

Text-mined interactions from Literome

Waehre et al., J Am Coll Cardiol 2003 (Coronary Artery Disease) : Our main findings were : 1 ) gene expression of several chemokines ( i.e., macrophage inflammatory protein [MIP ] -1alpha, MIP-1beta, and interleukin [ IL]-8 ) and chemokine receptors ( i.e., CC chemokine receptor [ CCR]1, CCR2, CCR4, and CCR5 ) was markedly increased among CAD patients compared with healthy control subjects ; 2 ) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines ( i.e., MIP-1alpha, MIP-1beta, IL-8 ) and receptors ( i.e., CCR1 and CCR2 ), with the most pronounced effect in the atorvastatin group ; and 3 ) statin therapy reduced the spontaneous release of IL-8 and MIP-1alpha from PBMCs in CAD patients
Ellaban et al., Cell Immunol 2004 (Cecal Diseases...) : While production of IL-6 and KC was reduced, secretion of TNF-alpha and MIP-1alpha was enhanced in those cells isolated from mice with mild sepsis
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation...) : H/R ( 3 h/1 h ) significantly induced KC, MCP-1, macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha, MCP-1, RANTES, MIP-1alpha , and MIP-2 ( but not KC ) by RAW264.7 cells
Wu et al., J Gen Virol 2010 (Adenoviridae Infections...) : The results showed that IL-8 and IL-6 were induced 8 h after infection and, by 24 h, levels of IL-8, IL-6, MIP-1alpha/beta and MCP-1 were all increased
Zhang et al., J Biol Chem 2013 : In vitro, IL-6 deficiency or Signal Transducer and Activator of Transcription 3 ( STAT3 ) knockdown in activated macrophage attenuated the expression of CCL2, CCL3 , but not CCL5, which resulted in less macrophage migration
Wang et al., Arthritis Rheum 2013 (Intervertebral Disc Degeneration...) : Tumor necrosis factor a- and interleukin-1ß dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
Dudley et al., Am J Reprod Immunol 1995 : IL-6 had no effect on MIP-1 alpha production
Dudley et al., J Soc Gynecol Investig 1996 : Macrophage inflammatory protein-I alpha regulates prostaglandin E2 and interleukin-6 production by human gestational tissues in vitro
Leng et al., J Immunol 1997 (Leukemia, Monocytic, Acute) : IL-11 did not similarly regulate monocyte/macrophage production of IL-8 or macrophage inflammatory protein-1alpha ( MIP-1alpha ) and IL-6 did not similarly inhibit IL-12 elaboration
Matsumoto et al., Int Immunol 1998 (Leukemia, Monocytic, Acute) : Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha , osteopontin and CD14 in a monocytic leukemia cell line ... We demonstrated that inducible expression of NF-IL6 is able to increase endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha , osteopontin and CD14 in M1 cells