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IL6 — TLR2
Text-mined interactions from Literome
Wang et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Furthermore, a specific
TLR2 blocking monoclonal antibody ( 2392 )
attenuated BLP induced, but not LPS induced, tumor necrosis factor-alpha and
interleukin-6 production, indicating BLP rather than LPS as a ligand for TLR2 engagement and activation
Matsumura et al., Immunology 2003
:
TRAF6-NF-kappaB pathway is essential for
interleukin-1 induced
TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
Oshikawa et al., Biochem Biophys Res Commun 2003
(Lung Diseases) :
The results demonstrated three patterns of gene expression : the
TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in
response to lipopolysaccharide (LPS),
interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Jang et al., J Immunol 2004
(Tuberculosis) :
A key new finding of this study is that production of
IL-6 and IL-10 from dendritic cells in response to M. tuberculosis is principally
dependent on
TLR2
Kurt-Jones et al., J Endotoxin Res 2004
:
MEFs were highly responsive to TLR-ligand activation and secreted high levels of both
IL-6 and MCP-1 in
response to
TLR ligands
Goral et al., J Immunol 2005
(Inflammation) :
Furthermore, different
TLR ligands
stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Seki et al., Hepatology 2005
:
However,
TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not
essential for NF-kappaB activation and
IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways ... However,
TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not
essential for NF-kappaB activation and
IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways
Hajishengallis et al., Infect Immun 2005
:
Induction of interleukin-1beta (IL-1beta),
IL-6 , IL-8, or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was
inhibited by
anti-TLR2 but not by anti-TLR4 antibody
Suliman et al., FASEB J 2005
:
In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with
TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ),
interleukin 6 , nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Zhang et al., EMBO J 2006
:
We found that the serine phosphorylation was crucial for
TLR induced
interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway
Kuwata et al., Immunity 2006
(Colitis...) :
IkappaBNS-deficient macrophages and dendritic cells show increased
TLR mediated expression of genes such as
IL-6 and IL-12p40, which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006
(Crohn Disease) :
Moreover, they lack MDP induced enhancement of
TLR mediated tumor necrosis factor alpha,
interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Pons et al., Respir Res 2006
(Pulmonary Disease, Chronic Obstructive) :
Finally, we demonstrated that
IL-6 , whose plasma levels are elevated in patients,
up-regulated in vitro
TLR-2 expression in monocytes from never smokers
Senn et al., J Biol Chem 2006
(Insulin Resistance) :
RNA interference mediated inhibition of
TLR2 and MyD88 expression in C2C12 muscle cells
resulted in a near complete inhibition of palmitate induced insulin resistance and
IL-6 production
Boyd et al., Cardiovasc Res 2006
(Myocarditis) :
Ligand activation of TLR2,
TLR4 and TLR5, but not TLR3, TLR7 or TLR9,
resulted in cardiomyocyte expression of the inflammatory cytokine
IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1 ... Ligand activation of
TLR2 , TLR4 and TLR5, but not TLR3, TLR7 or TLR9,
resulted in cardiomyocyte expression of the inflammatory cytokine
IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1
Flacher et al., J Immunol 2006
:
TLR2 and TLR3 ligands
increase IL-6 and IL-8 production, while dsRNA alone stimulates TNF-alpha release
Bsibsi et al., Glia 2007
:
Moreover, the CD14 triggered
TLR2 mediated response in astrocytes
lead to the production of CXCL8,
IL-6 , and IL12p40, whereas typical TLR induced pro-inflammatory cytokines, like TNF-alpha and IL-1beta, were not produced at detectable levels
Shu et al., Clin Exp Immunol 2007
:
natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha,
interleukin (IL)-6 and IL-12 p40 in
response to
Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Batra et al., Am J Pathol 2007
:
In WT preadipocytes the
TLR responsiveness
increased during maturation to adipocytes ; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher
interleukin-6 production
Iimuro et al., J Gastroenterol Hepatol 2007
:
In Myd88 ( -/- ) mice after PH, induction of expression of immediate early genes involved in hepatocyte replication and phosphorylation of signal transducer and activators of transcription 3 ( STAT3 ) in the liver, and production of TNF-alpha/IL-6 by and activation of NF-kappaB in the Kupffer cells were grossly subnormal and were associated with impaired liver regeneration, while
TLR2 , 4 and 9, which recognize Gram negative and -positive bacterial products, are not
essential for NF-kappaB activation and
IL-6 production after PH
Barr et al., Eur J Immunol 2007
:
In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the
role of
Toll-like receptors ( TLR ) in the control of secretion of
IL-6 , IL-10, IL-12 and IFN-gamma by B cells
Peiser et al., J Leukoc Biol 2008
(Inflammation) :
Application of anti-TLR1, anti-TLR6, and anti-TLR2 indicated an exclusive
role of
TLR2 in
IL-6 induction in human LCs. Collectively, our results show that TLR2 expressed by LCs mediates inflammatory responses to lipopeptides, which implicates a central role in sensing pathogens in human skin
Yu et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007
(Pneumonia...) :
Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as TNF-alpha and
IL-6 , attenuate NF-kappaB activity, and
inhibit TLR2 and TLR4 expression in polymicrobial sepsis
Conner et al., J Exp Med 2008
:
This gene emerged as a negative regulator of
TLR2 mediated
interleukin (IL)-6 production in MOLF/Ei mice, which expressed IRAK1BP1 mRNA in an allele-specific manner when crossed with the C57BL/6J strain
Taneichi et al., Clin Immunol 2008
(Agammaglobulinemia...) :
Stimulation with TLR2,
TLR4 and TLR7/8 ligands, as well as TLR3 ligand,
resulted in significantly lower production of TNF-alpha, but neither
IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls ... Stimulation with
TLR2 , TLR4 and TLR7/8 ligands, as well as TLR3 ligand,
resulted in significantly lower production of TNF-alpha, but neither
IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Bailey et al., Am J Physiol Lung Cell Mol Physiol 2008
:
To determine whether
TLR2 expression was being
regulated by
IL-6 , the production of IL-6 was blocked using an IL-6 neutralizing antibody
Prescott et al., J Allergy Clin Immunol 2008
(Hypersensitivity...) :
Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and
IL-6 responses to
TLR2 , TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Castillo et al., Nanomedicine (Lond) 2008
:
Ag @ tiopronin nanoparticles were not proinflammatory agents, but remarkably they specifically impaired the
IL-6 secretion
mediated by TLR2,
TLR2/6 , TLR3 or TLR9 stimulation in co-treatment experiments
Ospelt et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid...) :
Among the expressed TLRs,
TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C )
led to the most pronounced increase in
IL-6 , MMP-3, and MMP-13
Xie et al., Biochem Biophys Res Commun 2009
(Breast Neoplasms...) :
TLR2 activation
increased IL-6 , TGF-beta, VEGF and MMP9 secretion, which are associated with TLR2-NF-kappaB signaling
Lichtnekert et al., American journal of physiology. Renal physiology 2009
(Glomerulonephritis...) :
Exposure to necrotic cells activated cultured primary mesangial cells to produce
Il-6 in a
Tlr2/Myd88 dependent manner
Matsushita et al., Nature 2009
(Anemia...) :
Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of
interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in
response to
TLR ligands
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Tang et al., Zhongguo Dang Dai Er Ke Za Zhi 2009
(Herpes Simplex...) :
The production and release of
IL-6 and IL-10 might be
mediated by
TLR2 and TLR9
Nichols et al., Am J Pathol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
Mechanistically, PE DHC enhances EAE in mice lacking natural killer T cells, fails to enhance EAE in Toll-like receptor 2 (TLR2)-deficient mice and, in vitro, induces dendritic cell
interleukin-6 secretion in a
TLR2 dependent manner
Lanz et al., Stem Cells Dev 2010
(Encephalomyelitis, Autoimmune, Experimental) :
This failure to catabolize trp is not due to defective TLR signaling as demonstrated by
induction of
interleukin 6 (IL-6) by
TLR activation
Frazier et al., J Immunol 2009
(Escherichia coli Infections...) :
MAPKs are crucial for TNF-alpha and
IL-6 production by innate immune cells in
response to
TLR ligands
Suzuki et al., J Dent Res 2009
(Gingival Overgrowth) :
In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of
interleukin (IL)-6 and IL-8
induced by
TLR ligands, whereas phenytoin attenuated those responses
Weaver et al., Eur J Immunol 2010
:
Stimulation of C5aR ( -/- ) DC with OVA and
TLR2 ligand Pam ( 3 ) CSK ( 4 )
increased TGF-beta production and induced high levels of
IL-6 and IL-23 but only minor amounts of IL-12 leading to differentiation of Th cells producing IL-17A and IL-21
Fang et al., FEMS Immunol Med Microbiol 2010
(West Nile Fever) :
Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or
toll-like receptor ( TLR ) agonist treatment of gammadelta T cells
induced the production of IFN-gamma, tumor necrosis factor-alpha and
IL-6 , which are known to promote DC maturation
Amu et al., Scand J Immunol 2010
:
We found that CD25 ( + ) B cells secreted higher levels of
IL-6 , IL-10 and INFgamma in
response to different
TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Peña-Cruz et al., J Invest Dermatol 2010
:
PD-1 engagement on iLCs reduced
IL-6 and macrophage inflammatory protein (MIP)-1alpha cytokine production in
response to
TLR2 signals but had no effect on LC maturation
Han et al., Vet Microbiol 2010
:
Involvement of
TLR21 in baculovirus induced
interleukin-12 gene expression in avian macrophage-like cell line HD11
Wang et al., Infect Immun 2010
(Alveolar Bone Loss) :
Porphyromonas gingivalis produces unusual sphingolipids that are known to promote inflammatory reactions in gingival fibroblasts and
Toll-like receptor 2 (TLR2) dependent secretion of
interleukin-6 from dendritic cells
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010
(Hepatitis C, Chronic) :
TLR2 activation by the HCV core protein
leads to a decrease in
interleukin 6 (IL-6) production by human APCs after subsequent stimulation with TLR2 ( homotolerance ) ligands and TLR4 ( cross-tolerance ) ligands ... Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of
interleukin 17 by naive CD4 ( + ) T cells in the
presence of
TLR ligands
Müller et al., Infect Immun 2010
:
SitC not only induced a
TLR2 dependent release of
IL-6 in primary murine keratinocytes (MKs) but also induced intracellular accumulation of TLR2, which was time and concentration dependent
Hunter et al., TheScientificWorldJournal 2010
(Peritonitis) :
Selective inhibitors of Kv11.1 regulate
IL-6 expression by macrophages in
response to
TLR/IL-1R ligands
Xiang et al., Am J Pathol 2010
(Lymphoma...) :
Exosomes released from tumor cells having been shown to induce
interleukin-6 release from myeloid derived suppressor cells in a
Toll-like receptor 2/Stat3 dependent manner
Farges et al., Immunobiology 2011
:
We found that odontoblasts produce the pro-inflammatory cytokines
interleukin (IL)-6 and CXCL8, as well as the immunosuppressive cytokine IL-10 in
response to
TLR2 agonists
Haidl et al., Int Arch Allergy Immunol 2011
(Hypersensitivity) :
Increased mast cell
IL-6 production in
response to combined
TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation dependent conditions
Foldi et al., J Immunol 2010
:
Jagged1 induction was augmented by IFN-?, was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways, and elevated Jagged1 expression augmented
TLR induced
IL-6 production
Lin et al., J Cell Physiol 2011
(MAP Kinase Signaling System) :
Peptidoglycan
induces interleukin-6 expression through the
TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia
Chávez-Sánchez et al., Lipids in health and disease 2010
:
The activation of CD14,
TLR4 , and TLR2 by mmLDL
induces IL-1ß,
IL-6 , and IL-10 secretion in human monocytes and macrophages ... The activation of CD14, TLR4, and
TLR2 by mmLDL
induces IL-1ß,
IL-6 , and IL-10 secretion in human monocytes and macrophages
Lavoie et al., J Infect Dis 2010
(Infant, Premature, Diseases...) :
Preterm neonates had globally attenuated
TLR stimulated
interleukin (IL)-6 , interferon-a, and, to a lesser extent, tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes
Li et al., Cardiovascular diabetology 2010
:
Stimulation of
TLR2 or TLR4
induced NF-?B activation, and the expression of ICAM-1,
IL-6 and IL-8
Agarwal et al., Arthritis Res Ther 2011
(Fibrosis...) :
The ability of IFNa2 to regulate
TLR induced
interleukin (IL)-6 and CC chemokine ligand 2 production was also assessed
Jiang et al., Int Immunopharmacol 2011
(Sepsis...) :
Artesunate not only inhibited TNF-a and
IL-6 release but also
inhibited mRNA and protein expressions of
TLR2 and Nod2, two important receptors, in murine peritoneal macrophages stimulated with heat killed WHO-2, further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines
Vaquero et al., Hepatology 2011
:
CONCLUSION
: TLR-4 signaling
contributes to
IL-6 activation after PH, but the Tlr4 independent component appears sufficient for ensuring intact signaling downstream of IL-6
Ather et al., J Immunol 2011
(Disease Models, Animal...) :
Furthermore, SAA drives production of IL-1a, IL-1ß,
IL-6 , IL-23, and PGE ( 2 ), causes dendritic cell ( DC ) maturation, and
requires TLR2 , MyD88, and the NLRP3 inflammasome for secretion of IL-1ß by DCs and macrophages
Tang et al., Contrib Nephrol 2011
(Diabetic Nephropathies...) :
In human DN biopsies and PTEC,
TLR4is upregulated and
plays a permissive role in HG-induced
IL-6 and CCL-2 overexpression and monocyte transmigration
Séité et al., J Autoimmun 2011
(Autoimmune Diseases) :
As a result, IVIg suppresses
TLR induced production of the proinflammatory
IL-6 , but not that of the anti-inflammatory IL-10
Chung et al., J Viral Hepat 2011
(Hepatitis B...) :
We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with
TLR ligands
results in impaired
IL-6 production by peripheral blood monocytes from HCV infected patients
Liu et al., PloS one 2011
(Inflammation) :
We found that the expression of TNF-a and
IL-6 induced by
TLR2 engagement in uPAR-/- neutrophils was less than that in uPAR+/+ ( WT ) neutrophils
Jin et al., Mol Immunol 2011
(MAP Kinase Signaling System) :
Interestingly, results showed that while activation of either TLR4 or
TLR2/6 ( TLR2dimerized with TLR6 ), but not TLR2/1 ( TLR2dimerized with TLR1 ), significantly
increased IL-6 expression by U937 mononuclear cells, coactivation of TLR4 and TLR2/6, but not TLR4 and TLR2/1, led to a further augmentation on IL-6 expression by increasing IL-6 transcriptional activity, but not mRNA stability
Farrar et al., FASEB J 2012
(Disease Models, Animal...) :
Activation of
TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as
IL-6 and TNF-a
Jia et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2011
:
Pe-LPS can
induce the expression of
IL-6 in osteoblast MC3T3-E1 through CD-14 and TLR-4, but not
TLR-2
Wilhelmsen et al., Innate Immun 2012
(Sepsis) :
We found that
TLR2 activation specifically
induces the expression of the genes
IL-6 , IL-8, CSF2, CSF3, ICAM1 and SELE by human umbilical vein ECs and human lung microvascular ECs
Panda et al., J Reprod Immunol 2012
(Pre-Eclampsia) :
The expression of
TLR induced production of TNF-a, IFN-a,
IL-6 , and IL-12 were measured by multicolor flow cytometry
Hanamsagar et al., Trends Immunol 2012
:
TLR signaling
triggers the transcriptional activation of
pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Siggs et al., Blood 2012
:
Neither the missense nor the null allele affected
TLR induced secretion of
IL-6
DePaolo et al., J Exp Med 2012
(Inflammation...) :
Furthermore, induction of T ( H ) 17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of
TLR2/TLR1 induced
IL-6 and IL-23 and the presence of TGF-ß in the intestinal environment
Zamora et al., Cytokine 2012
:
Even though
TLR-activation induced TNFa, IL-10 and
IL-6 production, only recombinant TNFa was able to downregulate CD36
Som et al., Clinical and vaccine immunology : CVI 2012
(Disease Models, Animal...) :
Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF),
interleukin 6 (IL-6), and IL-10 in
response to S. aureus or LTA, but no other
TLR2 ligands
Kim et al., Microb Pathog 2013
:
In addition,
TLR4 was
required for the optimal production of
IL-6 , TNF-a, and IL-12 in BMDCs in response to A. baumannii
Miura et al., Hepatology 2013
(Fatty Liver...) :
Here we show that both
TLR2 and palmitic acid are
required for activation of the inflammasome,
interleukin (IL)-1a , and IL-1ß, resulting in the progression of NASH
Lee et al., Arterioscler Thromb Vasc Biol 2012
(Atherosclerosis) :
TLR 2 induces vascular smooth muscle cell migration through cAMP response element binding protein mediated
interleukin-6 production ...
TLR2 deficiency or inhibition of TLR2 signaling with anti-TLR2 antibody
suppressed TLR2 agonist induced VSMC migration and
IL-6 production, which was mediated via p38 mitogen associated protein kinase and extracellular signal regulated kinase 1/2 signaling pathways
Li et al., eLife 2012
:
A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger
TLR13 dependent
interleukin-1ß production
Melkamu et al., Journal of cell communication and signaling 2013
:
TLR2 up-regulation by poly I:C was also
reduced by
IL-6Ra-nAb and inhibitors of Jak2, Stat3 and NF-?B phosphorylation, whereas RANTES secretion was unaffected, but abolished following NF-?B inhibition
Koblansky et al., Immunity 2013
(Genetic Predisposition to Disease...) :
Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is
required for
interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Wang et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
Over expressing
TLR2 in BMDM
prevented CDA-2 and PG from inhibiting NF-?B activation, as well as induction of TNFa and
IL-6
Schamber-Reis et al., J Biol Chem 2013
(Disease Resistance...) :
Altogether, our results indicate the redundant and essential
role of nucleic acid sensing TLR3,
TLR7 and TLR9 in inducing
interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013
:
We showed that the hADSCs expressed Toll-like Receptors (TLR) 1,
TLR2 , TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly
induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß),
Interleukin-6 (IL-6) , and Interleukin-8 (IL-8) )
Karrich et al., Blood 2013
:
Although IL-21 did not affect
TLR induced type I IFNs,
IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Urbonaviciute et al., Arthritis Rheum 2013
(Kidney Diseases...) :
TLR-2 deficiency
prevented the pristane induced systemic release of
interleukin-6 (IL-6) and IL-10
Herath et al., PloS one 2013
(MAP Kinase Signaling System) :
METHODOLOGYPRINCIPAL FINDINGS : This study systematically investigated the effects of P. gingivalis LPS1435/1449 and LPS1690 on the expression of
TLR2 and TLR4 signal transduction and the
activation of pro-inflammatory cytokines
IL-6 and IL-8 in human gingival fibroblasts ( HGFs )
Giacomini et al., Eur J Immunol 2013
(Multiple Sclerosis, Relapsing-Remitting) :
Furthermore, in MS-derived PBMCs,
TLR7 mediated production of
IL-6 and the ex vivo expression of B-cell activating factor of the TNF family, two crucial cytokines for B-cell differentiation and survival, were induced by IFN-ß
Liu et al., J Neurosci 2013
:
In cultured neurons,
TLR7 activation
induced IL-6 and TNF-a expression through Myd88