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HGF — SMAD7

Text-mined interactions from Literome

Yang et al., Am J Pathol 2003 (Fibrosis) : To decipher the mechanism underlying HGF antagonizing TGF-beta1 's action, we examined the effects of HGF on TGF-beta1 mediated Smad signaling ... HGF neither inhibited Smad-2/3 phosphorylation and their association with Smad-4 induced by TGF-beta1, nor significantly affected inhibitory Smad-6 and -7 expression and cellular abundance of Smad transcriptional co-repressors in NRK-49F cells
Shukla et al., Am J Respir Cell Mol Biol 2009 (MAP Kinase Signaling System...) : HGF induced expression of Smad7 , an inhibitor of TGF-beta signaling, in a mitogen activated protein kinase dependent manner ... Thus, induction of Smad7 by HGF serves to limit acquisition of the myofibroblast phenotype in alveolar epithelial cells
de Caestecker et al., Genes Dev 1998 : We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase ( s ) downstream of MEK1