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STAT1 — TPO
Text-mined interactions from Literome
Erhardt et al., Exp Hematol 2009
(Thrombocytopenia) :
In signal transduction studies of washed human platelets, eltrombopag induced the phosphorylation signal transducers and activators of transcription ( STAT ) proteins with no phosphorylation of Akt, whereas recombinant human
TPO ( rhTPO )
induced the phosphorylation of Akt as well as
STAT-1 , -3, and -5
Pallard et al., EMBO J 1995
(Leukemia, Megakaryoblastic, Acute) :
We demonstrated that
TPO activates the kinase JAK2 and a STAT5-like transcriptional factor but not
STAT1 , STAT2, STAT3 or STAT4, in a very rapid and transient manner
Brizzi et al., J Clin Invest 1997
:
We demonstrate that PMN express the TPO receptor c-Mpl and that
TPO induces
STAT1 tyrosine phosphorylation and the formation of a serum inducible element complex containing STAT1