◀ Back to CXCL12

CXCL12 — XRCC5

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: XRCC5 → CXCL12 (increases)
  Evidence: ranscriptional response of selected cellular genes in Jurkat T cells upon SDF-1 exposure. Among the genes which showed a continuous increase in their expression following SDF-1 exposure were those involved in detoxification, DNA repair, apoptosis, TCR signal transduction, cytokinesis, cell adhesion molecules, chemokine receptors, and IFN-related molecules. The effects of MEK and PI3K inhibitors (50 µM PD098059 (20 21 ) and 20 µM LY294002 (22 ), respectively) on the expression of these genes ar...

Text-mined interactions from Literome

Katagiri et al., J Biol Chem 2004 : In Jurkat T cells, TCR cross linking triggered persistent Rap1 activation, and SDF-1 ( CXCL12 ) activated Rap1 transiently
Kanemitsu et al., Blood 2005 : In vitro, CXCL13 activated the small guanosine triphosphatase ( GTPase ) Rap1 in B cells, and corroborating this observation, a deficiency of RAPL, the Rap1 effector molecule, caused a significant reduction in shear-resistant B-cell adhesion to intercellular adhesion molecule 1 ( ICAM-1 )
Glodek et al., Leukemia 2007 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) : FAK-deficient REH cells also demonstrated reduced CXCL12 induced activation of the GTPase Rap1 , suggesting the importance of FAK in CXCL12 mediated integrin activation