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IGF1 — PARP12
Text-mined interactions from Literome
Spina Purrello et al., Mech Ageing Dev 2002
:
In this investigation the
effect of EGF, bFGF,
IGF-I or INS on nuclear
PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures ... In this investigation the
effect of EGF, bFGF,
IGF-I or INS on nuclear
PARP and mitochondrial ADPRT activities were assessed in nuclei and mitochondria purified from developing ( 30 DIV ) or aging ( 90 and 190 DIV ) primary rat astrocyte cultures
Wadsworth et al., Endocrinology 2004
:
Treatment with 150 microg/ml SPE for 24 h decreased
IGF-I induced proliferation of P69 cells and induced cleavage of the enzyme poly ( ADP-ribose ) polymerase (
PARP ), an index of apoptosis
Beckert et al., Biochem Biophys Res Commun 2006
:
Furthermore, the
IGF-I mediated inhibition of
PARP could be demonstrated as a result of protein phosphorylation since phosphorylation of PARP decreased its activity in vitro and IGF-I treatment of endothelial cells induced PARP phosphorylation ... The
IGF-I mediated phosphorylation and
inhibition of
PARP represent a novel mechanism of VEGF protein expression