Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
KDR
→
Complex of GNAQ-KDR
(directlyIncreases, GNAQ/KDR Activity)
Zeng et al., J Biol Chem 2003* Evidence: More importantly, we demonstrate that Gq/11 proteins interact with KDR in vivo, and the interaction of Gq/11 proteins with KDR does not require KDR tyrosine phosphorylation. Surprisingly, the Gq/11 antisense oligonucleotide completely inhibits VPF/VEGF-stimulated KDR phosphorylation. Expression of a constitutively active mutant of G11 but not Gq can cause phosphorylation of KDR and MAPK. In addition, a Gbetagamma minigene, hbetaARK1(495), inhibits VPF/VEGF-stimulated HUVEC proliferation, MAPK ph...
OpenBEL Selventa BEL large corpus:
GNAQ
→
KDR
(increases, KDR Activity, GNAQ Activity)
Zeng et al., J Biol Chem 2003* Evidence: Our most recent works show that pertussis toxin-sensitive G proteins and Gbetagamma subunits are required for Flt-1-mediated down-regulation of human umbilical vein endothelial cell (HUVEC) proliferation and that Gq/11 proteins are required for KDR-mediated RhoA activation and HUVEC migration.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *