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AKT3 — NOX5
Text-mined interactions from Literome
Cui et al., Inflamm Res 2000
:
These results suggest that the formation of F-actin is dependent on PI3-K and independent of PKC, ERK and p38 MAPK as well as the increase in intracellular Ca2+, whereas the activation of
NADPH oxidase is partly
dependent on ERK, p38 MAPK,
Akt regulated by PI3-K, and strongly dependent on the activation of PKC and the increase in intracellular Ca2+
Herkert et al., Circulation 2002
:
Furthermore, thrombin stimulated the phosphorylation of the PI 3-kinase target protein kinase
B/Akt in a redox-sensitive and
NADPH oxidase dependent manner
Hoyal et al., Proc Natl Acad Sci U S A 2003
:
Modulation of p47PHOX activity by site-specific phosphorylation :
Akt dependent activation of the
NADPH oxidase
Touyz et al., Arterioscler Thromb Vasc Biol 2005
:
The p47phox : actin interaction, through cortactin, plays an important role in Ang II-mediated site directed assembly of functionally active
NAD ( P ) H oxidase , ROS generation, and
activation of redox-sensitive p38MAP kinase and
Akt , but not ERK1/2
Xia et al., Hum Gene Ther 2004
(Brain Ischemia...) :
Enhanced cell survival after AM gene transfer was accompanied by markedly increased cerebral nitric oxide and Bcl-2 levels, as well as
Akt and GSK-3beta phosphorylation, but
reduced NADPH oxidase activity and superoxide production
Chen et al., Am J Physiol Heart Circ Physiol 2007
(Anoxia...) :
Our findings underscore the important
role of
NADPH oxidase and its subunit p47(phox) in modulating
Akt and ERK1/2 activation, angiogenic growth factor expression, and angiogenesis in myocardium undergoing I/R
Roy et al., Arch Biochem Biophys 2007
:
NADPH oxidase inhibitor, DPI ( Diphenyl iodide ), and pharmacological inhibitor of Akt,
Akt inhibitor IV, also showed a reduction in MDR1 expression, although not to the same extent as C-PC mediated inhibition of MDR1 expression
Abid et al., J Biol Chem 2007
:
The permissive
role of
NADPH oxidase on phosphoinositide
3-kinase-Akt-forkhead signaling is mediated at post-VEGF receptor levels and involves the nonreceptor tyrosine kinase Src
Stebbins et al., J Cardiovasc Pharmacol Ther 2008
:
Vascular endothelial growth factor induced activation of
Akt increased
NOx in treated ( 50 nM DHA ) versus untreated HCAEC ( 9.2 +/- 1.0 vs 3.3 +/- 1.1 micromol/microg protein/microL )
De Minicis et al., Hepatology 2008
(Disease Models, Animal...) :
Leptin induced phosphorylation of extracellular signal regulated kinase ( ERK ) and
AKT , but not of STAT3, was
blocked by
NADPH oxidase inhibition
Csibi et al., PloS one 2010
:
Inhibition of nitric oxide synthase and
NAD ( P ) Hoxidase and scavenging of free radicals with myricetin
restored insulin stimulated
Akt phosphorylation and GLUT4 translocation in the presence of Ang II
Chern et al., Planta Med 2011
(Cerebral Infarction...) :
Andrographolide inhibits
PI3K/AKT dependent
NOX2 and iNOS expression protecting mice against hypoxia/ischemia induced oxidative brain injury
Barale et al., Stem Cells Dev 2012
:
High glucose via
NOX dependent ROS generation and
AKT activity promotes adipose derived stem cell de-differentiation ... Thereby, our data indicate that HG via
NOX dependent
Akt activity induces ASC de-differentiation, and suggest that HG pre conditioning might be exploited for ASC ex-vivo expansion
Huang et al., Free Radic Biol Med 2012
(Carcinoma...) :
Accordingly, we suggest that
PI3K/AKT signaling
mediates TGIF induced
Nox2/p67(phox) complex activation and the resultant superoxide production which reinforces the PI3K/AKT signaling to promote the cellular migration/invasion ability of UC
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2012
(Colonic Neoplasms) :
These responses are related to intracellular reactive oxygen species ( ROS ) generation,
NADPH oxidase activation , and upregulation of
PI3K/Akt and hypoxia-inducible factor 1 alpha ( HIF-1a ) signaling
Yang et al., PloS one 2013
:
The AGEs stimulated
Akt activation was
blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2, an antioxidant NAC, superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate (
NAD ( P ) H ) oxidase inhibitor DPI, suggesting the involvement of Src and NAD ( P ) H oxidase in the activation of PI3-kinase-Akt pathway by AGEs