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CTNNB1 — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Spiegelman et al., Oncogene 2002
:
In the NIH3T3 cells, which express HOS, but not betaTrCP,
Wnt/beta-catenin signaling
leads to inhibition of HOS promoter activity and
NF-kappaB-driven transcription as well as to stabilization of beta-catenin
Tselepis et al., Oncogene 2002
(Adenocarcinoma...) :
This
beta-catenin mediated transcription is
independent of
NF-kappaB activation
Deng et al., Cancer Cell 2002
(Breast Neoplasms...) :
beta-catenin interacts with and
inhibits NF-kappa B in human colon and breast cancer ... Importantly, activated
beta-catenin was found to
inhibit the expression of
NF-kappa B target genes, including Fas and TRAF1 ... Furthermore, a strong inverse correlation was identified between the expression levels of beta-catenin and Fas in colon and breast tumor tissues, suggesting that
beta-catenin regulates
NF-kappa B and its targets in vivo
Deng et al., Mol Carcinog 2004
:
beta-catenin has been recently found to interact with and
inhibit nuclear factor kappa B (NF-kappaB)
Kuphal et al., Oncogene 2004
(Melanoma) :
Furthermore, cytoplasmatic
beta-catenin induced p38 and
NFkappaB activation in malignant melanoma ... In summary, we conclude that loss of E-cadherin and cytoplasmatic
beta-catenin induces p38 mediated
NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas
Zuscik et al., Environ Health Perspect 2007
:
Although Pb had no effect on basal CREB or
Wnt/beta-catenin pathway activity, it
induced NFkappaB signaling and inhibited AP-1 signaling
Cho et al., FEBS Lett 2008
(Neoplasms) :
Downregulation of lzts2 increased the beta-catenin/Tcf promoter activity and inhibited
NF-kappaB induced modulation of the nuclear translocation of
beta-catenin
Zhang et al., Dev Cell 2009
:
We find that
Wnt/beta-catenin signaling is absolutely
required for
NF-kappaB activation, and that Edar is a direct Wnt target gene