◀ Back to RELA

PTPN11 — RELA

Text-mined interactions from Literome

Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : TNF-alpha mediated JNK, c-Jun, and NF-kappaB activation required Src and SHP-2 activity ... A catalytically inactive form of SHP-2 increased MEKK3/Gab1 interaction and inhibited MEKK3 ( but not MEKK1 ) -mediated c-Jun and NF-kappaB activation
Kapoor et al., Mol Cell Biol 2004 (Glioblastoma) : On the other hand, ectopic overexpression of either a Gab1 mutant incapable of binding to SHP-2 ( Y627F ) or a phosphatase-inactive SHP-2 mutant ( C459S ) caused a significant increase in NF-kappaB activity
Wilson et al., J Virol 2008 : We report that expression of WNV NS1 inhibits TLR3 induced transcriptional activation of the IFN-beta promoter and of an NF-kappaB-responsive promoter
Bakken et al., Virology 2010 : We find that vGPCR activity results in phosphorylation of regulatory tyrosines in Shp2 and that in turn, Shp2 is required for vGPCR mediated activation of MEK, NFkappaB , and AP-1
Moffatt et al., J Virol 1998 : Furthermore, using pentoxifylline, an inhibitor of NF-kappaB activation, we demonstrate that the NF-kappaB mediated IL-6 activation by NS1 is uncoupled from the apoptotic pathway