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AKR1C1 — PRL

Text-mined interactions from Literome

Telleria et al., J Mol Endocrinol 2004 : In summary, we have shown that : ( i ) NFkappaB is expressed within the CL, primary luteinized granulosa cells, and a rat luteal cell line ; ( ii ) NFkappaB activation within the CL is developmentally regulated in pregnancy, depends on the age of the gland, and can be upregulated by prolactin ; ( iii ) inhibition of NFkappaB/p65 binding to an NFkappaB DNA consensus sequence correlates with induction of cell death in ovarian luteinized granulosa cells ; and ( iv ) overexpression of NFkappaB in luteal cells inhibits 20alphaHSD gene expression
Bao et al., Endocrinology 2007 : Our results further suggest that PRL inhibition of 20alpha-HSD expression is at the level of transcription and that decidual PRL ( dPRL ) inhibits 20alpha-HSD promoter activity
Matsuyama et al., Endocrinology 1990 : In this study, we investigated the effects of PRL and transforming growth factor-beta ( TGF beta ) on the 20 alpha HSD activity of rat luteal cells in vitro and examined whether TGF beta is involved in the luteotropic action of PRL ... Furthermore, the suppressive effect of PRL on 20 alpha HSD activity was significantly attenuated by anti-TGF beta antibody
Yoshida et al., Nihon Sanka Fujinka Gakkai Zasshi 1987 : Both hCG and PRL stimulated the 20 alpha-HSD activity
Zhong et al., Biochem Biophys Res Commun 1997 : Prolactin mediated inhibition of 20alpha-hydroxysteroid dehydrogenase gene expression and the tyrosine kinase system ... Although both JAK2 and Stat5 were phosphorylated on tyrosine upon PRL treatment, the PRL mediated inhibition of 20alpha-HSD was not reversed by either tyrosine kinase inhibitors, AG18 and genistein, but was largely reversed by the protein synthesis inhibitor cycloheximide