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ESR1 — HDAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated nuclear estrogen receptor alpha network: LMO4 (LMO4) → ERA/MTA1/HDAC1/LMO4 complex (ESR1-MTA1-HDAC1-LMO4) (modification, collaborate)
  Mazumdar et al., Nat Cell Biol 2001, Singh et al., Cancer Res 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: ER alpha (ESR1) → ERA/MTA1/HDAC1/LMO4 complex (ESR1-MTA1-HDAC1-LMO4) (modification, collaborate)
  Mazumdar et al., Nat Cell Biol 2001, Singh et al., Cancer Res 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: ER alpha (ESR1) → HDAC1 (HDAC1) (modification, collaborate) Mazumdar et al., Nat Cell Biol 2001, Singh et al., Cancer Res 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: ERA/MTA1/HDAC1/LMO4 complex (ESR1-MTA1-HDAC1-LMO4) → MTA1 (MTA1) (modification, collaborate) Mazumdar et al., Nat Cell Biol 2001, Singh et al., Cancer Res 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated nuclear estrogen receptor alpha network: ERA/MTA1/HDAC1/LMO4 complex (ESR1-MTA1-HDAC1-LMO4) → HDAC1 (HDAC1) (modification, collaborate) Mazumdar et al., Nat Cell Biol 2001, Singh et al., Cancer Res 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: HDAC1 — ESR1 (coimmunoprecipitation) Kawai et al., Int J Cancer 2003*
• IRef Bind_translation Interaction: HDAC1 — ESR1 (affinity chromatography technology) Kawai et al., Int J Cancer 2003*
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Okada et al., EMBO Rep 2008
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Tarallo et al., Proteomics 2011
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Kawai et al., Int J Cancer 2003*
• IRef Biogrid Interaction: HDAC1 — ESR1 (direct interaction, pull down) Kawai et al., Int J Cancer 2003*
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Varshochi et al., J Biol Chem 2005*
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Kurtev et al., J Biol Chem 2004
• IRef Biogrid Interaction: HDAC1 — ESR1 (colocalization, imaging technique) Liu et al., J Biol Chem 2004*
• IRef Biogrid Interaction: HDAC1 — ESR1 (physical association, affinity chromatography technology) Itoh et al., J Immunol 2007*
• IRef Intact Interaction: Complex of CHD3-MTA1-HDAC1-ESR1 (association, anti bait coimmunoprecipitation) Okada et al., EMBO Rep 2008
• IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation) Okada et al., EMBO Rep 2008

Text-mined interactions from Literome

Macaluso et al., Oncogene 2003 (Breast Neoplasms) : pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer
Kawai et al., Int J Cancer 2003 (Breast Neoplasms...) : Interestingly, overexpression of HDAC1 in stable transfected MCF-7 clones induced loss of ER-alpha and significantly increased cell proliferation and colony formation, as compared to the control MCF-7 cells, whereas treatment of stable MCF-7 clones with the HDAC specific inhibitor trichostatin A (TSA) induced re-expression of ER-alpha mRNA and protein
Keen et al., Breast Cancer Res Treat 2003 (Breast Neoplasms) : A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha ( ER ) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine
Margueron et al., J Mol Endocrinol 2004 (Breast Neoplasms) : In this study, we have analysed the effects of histone deacetylase (HDAC) inhibition on estrogen receptor ( ER ) expression and on its transcriptional activity in response to antiestrogens
Ellison-Zelski et al., Mol Cell Biol 2009 : Reduction of Sin3A expression by RNA interference specifically inhibits estrogen induced repression of ESR1
Khurana et al., J Biol Chem 2011 (Breast Neoplasms) : In contrast, histone deacetylase 7 (HDAC7) inhibits estrogen receptor a ( ERa ) -mediated transcription