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IL1B — P2RX7

Text-mined interactions from Literome

Grahames et al., Br J Pharmacol 1999 : 6. In conclusion our data confirm the involvement of P2X7 receptors in ATP induced IL-1beta release in human monocytes
Brough et al., Mol Cell Neurosci 2002 (Encephalitis...) : Thus, IL-1beta is not required for P2X7 receptor stimulated microglial death
Gudipaty et al., Am J Physiol Cell Physiol 2003 (Calcium Signaling) : Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells
Verhoef et al., J Immunol 2003 : P2X7 receptor dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release ... To investigate the relationship between the P2X7R dependent changes in plasma membrane organization and the release of IL-1 beta , we generated time-lapse movies of ATP stimulated BAC1 murine macrophages in conjunction with biochemical analyses of IL-1 beta release ... Thus, P2X7R activation signals distinct, novel membrane blebbing events ( dependent on RhoA activation and Rho-effector kinase activity ) and simultaneously initiates release of IL-1 beta
Colomar et al., J Biol Chem 2003 : Maturation and release of interleukin-1beta by lipopolysaccharide primed mouse Schwann cells require the stimulation of P2X7 receptors ... Taken together, these results show that P2X7 receptor stimulation and associated BK channels, through the activation of ICE, leads to the maturation and the release of IL-1beta by immune challenged Schwann cells
Donnelly-Roberts et al., J Pharmacol Exp Ther 2004 (MAP Kinase Signaling System) : In contrast, P2X(7)R mediated IL-1beta release is dependent on caspase activity but not p38 MAPK
Verhoef et al., Mol Pharmacol 2004 (Blister) : We therefore tested whether MTX treatment of lipopolysaccharide primed murine macrophages would mimic the ability of activated P2X7R to induce secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta)
Chen et al., Inflamm Res 2005 (Inflammation) : P2X(7) mediated IL-1beta release in RPC and the effect of PPADS were determined ... Activation of P2X(7) receptors on RPC resulted in IL-1 beta secretion, which was inhibited by PPADS
Verhoef et al., J Immunol 2005 : Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor ... This cytolysis was repressed by the cytoprotectant glycine, permitting dissociation of P2X7R regulated secretion of mature IL-1beta from the lytic release of pro-IL-1beta
López-Castejón et al., Mol Immunol 2007 (Ion Channel Gating) : We used this information to further investigate the mechanisms of IL-1beta release induced by mammalian and fish P2X(7) receptors ... However, activation of rat P2X(7) receptors ectopically expressed in HEK293 together with human ICE led to the specific secretion of unprocessed seabream IL-1beta ... In contrast, neither seabream nor zebrafish P2X(7) receptors induced the secretion of mammalian or fish IL-1beta when expressed in HEK293, while a chimeric receptor harboring the ATP binding domain of seabream P2X(7) and the intracellular region of its rat counterpart did so ... These findings indicate that P2X(7) receptor mediated activation of ICE and release of IL-1beta result from different downstream signaling pathways and suggest that although the mechanisms involved in IL-1beta secretion are conserved throughout evolution, distinct inflammatory signals have been selected for the secretion of this cytokine in different vertebrates
Pelegrin et al., EMBO J 2006 : Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation
Pelegrin et al., J Biol Chem 2007 : Blockade of pannexin-1 in macrophage endogenously expressing the ATP gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1beta (IL-1beta) in response to P2X7R activation
Stock et al., J Immunol 2006 : Neither LPC induced IL-1beta release nor LPC stimulated intracellular Ca ( 2+ ) increases were affected by inhibition of P2X(7) ATP receptors with oxidized ATP
Wilson et al., Br J Pharmacol 2007 : Activation of P2X(7)Rs resulted in low-level release of bioactive IL-1beta and simultaneous release of IL-1Ra
Franchi et al., J Biol Chem 2007 (Bacterial Infections...) : However, the roles of P2X7 receptor and intracellular K ( + ) in IL-1beta secretion induced by bacterial infection remain unknown
Qu et al., J Immunol 2007 (Inflammation) : We compared the contribution of these mechanisms to P2X7R stimulated IL-1 beta secretion in primary bone marrow derived macrophages isolated from wild-type, P2X7R knockout, or apoptosis associated speck-like protein containing a C-terminal CARD knockout mice
Mingam et al., Brain Behav Immun 2008 : In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury : a crucial role of P2X7 receptor mediated IL-1beta release
Pelegrin et al., J Immunol 2008 : Activation of purinergic P2X(7) receptors ( P2X(7)R ) by extracellular ATP is a key physiological inducer of rapid IL-1beta release from LPS primed macrophage ... We used peritoneal macrophage from P2X(7)R ( -/- ) mice and found that release of IL-1alpha, IL-18, as well as IL-1beta , by ATP resulted exclusively from activation of P2X(7)R , release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1 dependent and -independent component to IL-1beta release
Takenouchi et al., J Immunol 2008 : The P2X7 receptor (P2X7R) , an ATP gated ion channel, plays essential roles in the release and maturation of IL-1beta in microglial cells in the brain ... In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells
Hewinson et al., J Immunol 2008 (Ion Channel Gating) : These data demonstrate that signaling via NADPH oxidase activity is fundamental for the processing of mature IL-1beta induced by P2X(7)R stimulation
Pelegrin et al., Purinergic Signal 2009 : Inhibition of pannexin-1 blocks P2X(7)R mediated IL-1beta release from macrophage as well as release mediated by other stimuli which couple to activation of capase-1 and additionally inhibits the release of interleukin-1alpha, a member of the IL-1 family whose processing does not require caspase-1 activation
Honore et al., Behav Brain Res 2009 (Pain) : These data demonstrate that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of inflammatory pain and suggest that the antihyperalgesic effects of P2X7 receptor blockade in an inflammatory pain model in mice are mediated by blocking the release of IL-1beta
Labrousse et al., PloS one 2009 (Memory Disorders) : We have previously shown that IL-1beta synthesis in the hippocampus is dependent on P2X(7) receptor ( P2X(7)R ), which is an ionotropic receptor of ATP
Clark et al., J Neurosci 2010 (Hyperalgesia) : P2X7 dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide ... Here we examine the involvement of the purinergic P2X7 receptor in the release of IL-1beta following activation of Toll-like receptor-4 (TLR4) in the dorsal horn, which is associated with nociceptive behavior and microglial activation ... We observed that lipopolysaccharide (LPS) induced release of IL-1beta was prevented by pharmacological inhibition of the P2X7 receptor with A-438079, and was absent in spinal cord slices taken from P2X7 knock-out mice ... Application of ATP did not evoke release of IL-1beta from the dorsal horn unless preceded by an LPS priming stimulus, and this release was dependent on P2X7 receptor activation
Cesaro et al., Am J Physiol Gastrointest Liver Physiol 2010 (Inflammatory Bowel Diseases) : The aims of the present study were 1 ) to examine P2X(7)R expression in IEC ( T84 cells ) and in human intestinal biopsies ; 2 ) to detect any changes in P2X(7)R expression in T84 cells during PMNL transepithelial migration, and during the active and quiescent phases of IBD ; and 3 ) to test whether P2X(7)R stimulation in T84 monolayers can induce caspase-1 activation and IL-1beta release by IEC
Mishra et al., J Biomed Sci 2013 : The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta (IL-1beta) and IL-18 production and release