◀ Back to NFKB1
HSPB1 — NFKB1
Pathways - manually collected, often from reviews:
-
KEGG Amoebiasis:
HSPB1
→
NFKB1/RELA
(protein-protein, inhibition)
Text-mined interactions from Literome
Kammanadiminti et al., J Biol Chem 2006
(Colitis) :
Gene silencing by small interfering RNA confirmed the
role of
Hsp27 in suppressing
NF-kappaB activation at IkappaB kinase (IKK) level
Sur et al., J Invest Dermatol 2008
:
Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating
NF-kappaB signaling ... Further studies showed that downregulation of
Hsp27 resulted in induction of
NF-kappaB reporter activity in keratinocytes
Voegeli et al., Appl Physiol Nutr Metab 2008
:
The
role of
Hsp27 and Hsp70 in
NF-kappaB activation is reviewed here, along with evidence suggesting that HSPs regulate Ang II-induced blood pressure through the regulation of NF-kappaB
Bao et al., Mol Pharmacol 2009
:
Correspondingly, the elevated
HSP27 and HSP70
suppressed inhibitor kappaB degradation and
nuclear factor kappaB (NF-kappaB) activation that were caused by ConA
Guo et al., BMC cancer 2009
(Carcinoma, Hepatocellular...) :
Altogether, these findings revealed a possible effect of HSP27 on apoptosis in metastatic HCC cells, in which
HSP27 may
regulate NF-kB pathway activation
Dodd et al., FASEB J 2009
(Atrophy) :
Hsp27 inhibits IKKbeta induced
NF-kappaB activity and skeletal muscle atrophy ... Previous work, in nonmuscle cells, has shown that
Hsp27 inhibits TNF-alpha induced
NF-kappaB activation ... During skeletal muscle disuse,
Hsp25/27 levels are decreased and
NF-kappaB activity
increased , and this increase in NF-kappaB activity is required for disuse muscle atrophy
Liu et al., Cell Immunol 2010
(Inflammation) :
Further studies have shown that
HSP27 regulated LPS induced activation of
NF-kappaB by interacting with TRAF6 and increasing the association of TRAF6-IKKgamma