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NAMPT — NFKB1

Text-mined interactions from Literome

Moschen et al., J Immunol 2007 (Inflammation...) : Visfatin induced effects involve p38 as well as MEK1 pathways as determined by inhibition with MAPK inhibitors and we observed activation of NF-kappaB
Adya et al., Diabetes Care 2008 (Diabetes Mellitus, Type 2...) : We investigated the activation of nuclear factor-kappaB (NF-kappaB) , a well-known proinflammatory transcription factor, by visfatin in endothelial cells ... Visfatin significantly increased NF-kappaB transcriptional activity ( P < 0.001 ) ... Visfatin induced NF-kappaB signaling in human endothelial cells affects the activation of gelatinases MMP-2 and -9, suggesting an important role of visfatin in the pathogenesis of vascular inflammation in obesity and type 2 diabetes
Lee et al., Int J Obes Relat Metab Disord 2009 : Electrophoretic mobility shift assay confirmed that visfatin increased the DNA binding activity of NF-kappaB ... Our findings suggest that visfatin causes endothelial dysfunction by increasing inflammatory and adhesion molecule expression at least partly through the upregulation of NF-kappaB activity
Romacho et al., Diabetologia 2009 (Diabetes Mellitus...) : By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB ... However, exogenous nicotinamide mononucleotide, the product of NAMPT activity, mimicked NF-kappaB activation and iNOS induction by ePBEF/NAMPT/visfatin, while the NAMPT inhibitor APO866 prevented the effects of ePBEF/NAMPT/visfatin on iNOS and NF-kappaB
Kang et al., Diabetes Res Clin Pract 2010 (Diabetes Mellitus, Type 2...) : These findings suggest that visfatin synthesis is activated from adipose tissue in a diabetic environment, induces NF-kappaB activation and leads to activation of pro-inflammatory cytokines and systemic inflammation
Huang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010 : NF-kappaB was also activated in these cells by visfatin and these effects could be significantly attenuated by Bay11-7082