Rodríguez et al., Cell Signal 2006
:
Cot is activated by LPS , by inducing its dissociation from the inactive p105 NFkappaB-Cot complex in macrophages
López-Pelaéz et al., Mol Biol Cell 2012
(Inflammation...) :
The dissociation of the 4E-BP-eIF4E complex, a key event in the cap dependent mRNA translation initiation, is dramatically reduced in LPS stimulated Cot/tpl2-knockout ( KO ) macrophages versus LPS stimulated wild-type ( Wt ) macrophages