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FADD — IRF6
Text-mined interactions from Literome
Bannerman et al., J Clin Invest 2002
:
The
Fas associated death domain protein suppresses activation of NF-kappa B by
LPS and IL-1 beta ... In the present report, we investigated whether
FADD could
mediate LPS activation of NF-kappa B ... Together, these data indicate that
FADD negatively
regulates LPS- and IL-1 beta induced NF-kappa B activation and that this regulation occurs upstream of I kappa B degradation
Zhande et al., Mol Cell Biol 2007
:
LPS stimulation
increases IRAK1-FADD interaction and recruitment of the IRAK1-FADD complex to activated MyD88 ... Functionally, enforced
FADD expression
inhibited LPS- but not vascular endothelial growth factor induced endothelial cell sprouting, while FADD deficiency led to enhanced production of proinflammatory cytokines induced by stimulation of TLR4 and TLR2, but not TLR3
Young et al., J Biol Chem 2011
(Influenza, Human...) :
Conversely, a reduction of
FADD and TRIM21 levels
leads to higher IFN-a induction,
IRF7 phosphorylation, and lower titers of RNA virus of infected cells