Das et al., J Immunol 2001
(Disease Progression...) :
mRNA expression and flow cytometric analysis of infected spleen cells suggested that cystatin and IFN-gamma treatment, in addition to greatly reducing parasite numbers, resulted in reduced levels of IL-4 but increased levels of IL-12 and inducible NO synthase
Schierack et al., Infect Immun 2003
:
Whereas filarial cystatins markedly increased the production of interleukin (IL)-10, C. elegans cystatins increased the production of IL-12 and gamma interferon ( IFN-gamma ) by human PBMC
Hartmann et al., Int J Parasitol 2003
(Nematode Infections) :
Caenorhabditis elegans cystatins induce the production of the Th1 cytokine IL-12 , in contrast to filarial cystatins that upregulate IL-10