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EPO — GATA1
Text-mined interactions from Literome
Ogilvie et al., J Biol Chem 2000
:
In erythroid progenitor cells,
Epo stimulates induction of transcription factor
GATA-1 and EpoR ; in C2C12 cells, GATA-3 and EpoR expression are induced
Zhao et al., Blood 2006
:
The PI3-kinase/AKT signaling pathway is identified as a mediator of
Epo induced phosphorylation of
GATA-1
Chiba et al., Nucleic Acids Res 1991
(Leukemia, Erythroblastic, Acute) :
Taken together with other observations, these results suggested the following scheme of erythroid differentiation : 1 ) GATA-1 is expressed in the early stage of blood cell development ; 2 ) GATA-1 transactivates the erythropoietin receptor gene ; 3 )
erythropoietin binds its receptor and the receptor mediated signals
enhance GATA-1 gene expression in erythroid progenitor cells ; and 4 ) GATA-1 finally transactivates hemoglobin synthesis related genes and globin genes in relatively matured erythroid cells
Horie et al., Int J Sports Med 2011
:
Expression of the
ERYTHROPOIETIN gene is negatively
controlled by the transcription factor
GATA binding protein ( GATA )
Delehanty et al., Blood 2012
(Anemia) :
Here we show that
erythropoietin regulates
GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation
Katakura et al., Dev Comp Immunol 2013
:
Recombinant goldfish
erythropoietin induced proliferation of progenitor cells in a dose dependent manner, and
up-regulated the expression of erythroid transcription factors
gata1 and lmo2 in progenitor cells
Lin et al., PloS one 2013
:
Here, we demonstrate that phosphorylation of
GATA-1 at serine ( 26 ) is also transiently
induced in cells of the erythroid lineage ( primary erythroblasts and erythrocyte committed progenitors [ EPs ] ) by
erythropoietin (EPO) , the principal cytokine regulating erythropoiesis
Busfield et al., Eur J Biochem 1995
:
The major erythroid DNA binding protein
GATA-1 is
stimulated by
erythropoietin but not by chemical inducers of erythroid differentiation ... Premature removal of
erythropoietin from culture
resulted in submaximal
GATA-1 , globin, and hemoglobin production
Aird et al., J Biol Chem 1994
:
The functional significance of the inhibition of preinitiation complexes is supported by in vitro transcription assays in which transcription from the PF4 and
erythropoietin core promoters is
suppressed by
GATA-1
Nicolis et al., Exp Hematol 1993
:
Erythroid differentiation involves the activation of a number of erythroid-specific genes, most of which, including the globin genes and the
erythropoietin receptor (Epo-R) gene, are, at least in part,
regulated by the transcription factor
GATA-1
Hoefsloot et al., Blood 1997
(Myelodysplastic Syndromes) :
Epo dependent DNA synthesis as well as
induction of
GATA-1 binding activity in marrow cells from 15 MDS cases were severely reduced as compared with normal bone marrow ( NBM )
Moroni et al., Biochem Biophys Res Commun 1997
:
However, when grown in vitro, they rapidly express
GATA-1 from the testis promoter in the
presence of
Erythropoietin (Epo) but not in that of other growth factors
Sharlow et al., Blood 1997
(Leukemia, Erythroblastic, Acute) :
No
effects of
EPO on levels of HCP, Syp, Stat5, the EPO receptor, or
GATA-1 expression were observed during induced differentiation
Joneja et al., Blood 1997
:
In FDC2-ER cells, the ectopic expression of
GATA-1 had no detectable effect on
Epo inhibition of apoptosis