◀ Back to MAPK8
MAPK8 — PLA2G4A
Text-mined interactions from Literome
Gijón et al., J Leukoc Biol 1999
:
In macrophages, zymosan induces a transient increase in intracellular calcium and activation of
MAPK , which together fully
activate cPLA2 and synergistically promote arachidonic acid release
Geijsen et al., FEBS Lett 2000
(MAP Kinase Signaling System) :
Cytokine mediated
cPLA(2) phosphorylation is
regulated by multiple
MAPK family members ... GM-CSF induced
cPLA(2) phosphorylation was not
affected by pharmacological inhibition of p38
MAPK , phosphatidylinositol 3-kinase or Src
Fonteh et al., J Immunol 2000
:
Additionally, an inhibitor of p44/p42
mitogen activated protein kinase ( PD98059 ) significantly
inhibited sPLA2 induced
cPLA2 activation and AA release
Wen et al., J Cell Biochem 2000
:
On the other hand, rottlerin ( the selective PKCdelta inhibitor ), SB 203580 ( the selective p38
MAPK inhibitor ), and wortmannin ( the PI 3-kinase inhibitor ) can
affect neither
cPLA(2) nor ERK phosphorylation
Sano et al., J Immunol 2001
:
Preincubation of eosinophils with U0126 or PD98059, two structurally unrelated
MAPK kinase inhibitors, or arachidonic trifluoromethyl ketone, a
cPLA(2) inhibitor , blocked eosinophil adhesion to FN
Siegel et al., J Biol Chem 2001
(Calcium Signaling...) :
Agonist induced activation of
cPLA2 involves
mitogen activated protein kinase ( MAPK ) activation
Misra et al., Arch Biochem Biophys 2001
(Calcium Signaling...) :
We conclude that alpha2M* induced
cPLA2 synthesis is
controlled by [ Ca2+ ] i levels, tyrosine kinase activity, the p21ras dependent
MAPK and PI 3-kinase downstream signaling pathways, and regulation of NFkappaB
Zhu et al., J Immunol 2001
(MAP Kinase Signaling System) :
We also find that
cPLA(2) activation caused by fMLP occurs subsequent to and is
dependent upon ERK1/2 and p38
MAPK activation
Kalyankrishna et al., J Pharmacol Exp Ther 2003
:
NE-induced p38
MAPK activation was found to be mediated through the stimulation of alpha-1 and alpha-2 adrenergic receptors, was dependent on extracellular Ca ( 2+ ), and was
attenuated by an inhibitor of
cPLA(2) ( pyrrolidine-1 ) ... Moreover, the
cPLA(2) product, AA,
activated p38
MAPK in VSMC
Chakraborti et al., Cell Signal 2003
(MAP Kinase Signaling System) :
Recently, a negative feed back loop for
cPLA(2) activation by
MAPK has been proposed
Li et al., J Pharmacol Exp Ther 2005
:
These data indicate that Ang II-stimulated Akt activity is mediated by
cPLA(2) dependent, p38
MAPK regulated PLD(2) activation and EGFR transactivation
Leoncini et al., Journal of thrombosis and haemostasis : JTH 2006
(Calcium Signaling) :
The
cPLA2 phosphorylation and activation were both
impaired by the inhibition of p38
MAPK through SB203580
Engelbrecht et al., Prostaglandins Leukot Essent Fatty Acids 2007
(MAP Kinase Signaling System...) :
Therefore, the aim of this study was to investigate the
role of
cPLA(2) in
MAPK phosphorylation and apoptosis in simulated ischaemia/reperfusion ( SI/R ) -induced injury in neonatal cardiomyocytes
Kang et al., Int Arch Allergy Immunol 2008
(Anaphylaxis) :
TNF-alpha-induces
cPLA(2) activation through the pathway
involving p38
MAPK and ERK activation and appears to be the key mechanism leading to the development of late-phase anaphylaxis
Hoffmann et al., Biochim Biophys Acta 2010
:
Hyperforin induced phosphorylation of
cPLA(2) at Ser505 and activated p38 mitogen activated protein kinase ( MAPK ), and inhibition of p38
MAPK by SB203580
prevented cPLA(2) phosphorylation
Wang et al., Invest Ophthalmol Vis Sci 2011
:
cPLA(2)a is
regulated by calcium mobilization and mitogen activated protein kinases (
MAPK ) activation
Slomiany et al., Inflammopharmacology 2013
:
Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on
MAPK/ERK mediated
activation of IKK-ß and
cPLA2 : modulatory effect of ghrelin
Börsch-Haubold et al., J Biol Chem 1995
:
Collagen, thrombin, and PDBu induced phosphorylation of platelet
cPLA2 as well as
activation of
mitogen activated protein kinase ( MAPK ; p42mapk and p44mapk ) ... Although
MAPK may
underlie phosphorylation of
cPLA2 in PDBu activated human platelets, our results provide evidence for PKC- and MAPK independent phosphorylation of cPLA2 in platelets stimulated by the physiological activators collagen and thrombin
Sa et al., J Biol Chem 1995
:
Since arachidonate release is required for basic FGF stimulated motility of EC, our results show that p42
mitogen activated protein kinase activation of
cPLA2 may be a regulatory event in stimulation of cellular release of this important eicosanoid precursor during cellular responses to basic FGF
Sakanaka et al., Biochem Biophys Res Commun 1994
:
SSTR4 activated
mitogen activated protein ( MAP ) kinase and
induced the phosphorylation of 85kDa
cytosolic phospholipase A2 (cPLA2) , in a PTX-sensitive manner
Hernández et al., Biochem J 1997
(Astrocytoma) :
Evidence that the cytosolic phospholipase A2 (cPLA2) takes part in thrombin induced arachidonate release was provided by the finding that thrombin induced retardation of the mobility of cPLA2 in SDS/polyacrylamide gels, which is a feature of the
activation of
cPLA2 by
mitogen activated protein ( MAP ) kinases
Pyne et al., Biochem J 1997
:
This occurs via a pathway that involves : ( 1 ) the protein kinase C ( PKC ) -dependent activation of
mitogen activated protein kinase ( MAPK); (2 ) the MAPK dependent phosphorylation and
activation of
cytosolic phospholipase A2 (cPLA2) and ( 3 ) the utilization of cPLA2 derived arachidonate by the cyclo-oxygenase pathway to produce prostaglandin E2 ( PGE2 ) ... Acute treatment of ASM cells with PMA ( a direct activator of PKC ) also stimulated the
MAPK dependent phosphorylation of
cPLA2
Hayama et al., J Biochem 1997
:
These data suggest that glucose induced
cPLA2 activation through
MAPK activation is responsible for the enhancement of PGE2 production in mesangial cells
Nakahata et al., Nihon Yakurigaku Zasshi 1997
:
Then, MAPK is activated by a PKC pathway, then
cPLA2 is
activated by
MAPK
Husain et al., Biochim Biophys Acta 1998
:
The data presented are consistent with a
role for PKCalpha, but not for p42/p44
mitogen activated protein kinase ( MAPK ), in
cPLA2 activation and AA release in ET-1 stimulated CISM cells since : ( i ) the PKC inhibitor, RO 31-8220, inhibited ET-1 induced AA release, cPLA2 phosphorylation and cPLA2 activity, but had no inhibitory effect on p42/p44 MAPK activation, ( ii ) genistein, a tyrosine kinase inhibitor, inhibited ET-1 stimulated MAPK activity but had no inhibitory effect on AA release in the ET-1 stimulated cells
Cybulsky et al., Kidney Int 1998
(Glomerulonephritis, Membranous) :
The
role of p42
MAPK in
cPLA2 activation becomes redundant in the presence of relatively potent PKC activation
Pyne et al., Cell Signal 1998
:
cPLA2 is
regulated by
mitogen activated protein kinase ( MAPK ) in a number of cell types