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CCL5 — IL6
Text-mined interactions from Literome
Nanki et al., J Immunol 2001
(Arthritis, Rheumatoid) :
In this study we show that CCL2/monocyte chemotactic protein-1,
CCL5/RANTES , and CXCL12/stromal cell derived factor-1
enhanced IL-6 and IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Kim et al., J Neurochem 2004
:
Regulation of
RANTES/CCL5 expression in human astrocytes by
interleukin-1 and interferon-beta
Punturieri et al., J Immunol 2006
:
Synthetic OMP elicited strong release of
IL-6 , the principal inducer of airway mucin genes, and
induced CCL5 and CXCL10 from murine AMphi only when IFN-beta was also present
Tang et al., Arthritis Rheum 2010
(Osteoarthritis) :
This study was undertaken to investigate the intracellular signaling pathways involved in
CCL5 induced
interleukin-6 (IL-6) production in human synovial fibroblasts ...
CCL5 mediated
IL-6 expression was assessed by quantitative polymerase chain reaction and enzyme linked immunosorbent assay ... Stimulation of OASFs with
CCL5 induced concentration- and time dependent increases in
IL-6 production ...
CCL5 mediated
IL-6 production was attenuated by CCR5 monoclonal antibody, CCR5 inhibitor ( Met-RANTES ), and CCR5 siRNA ... The present results suggest that the interaction between
CCL5 and CCR5
increases IL-6 production in human synovial fibroblasts via the PKCd/c-Src/c-Jun and AP-1 signaling pathways
Elsawa et al., J Biol Chem 2011
(Neoplasms) :
CCL5 increases
IL-6 expression and secretion in bone marrow stromal cells ... Analysis of the mechanism reveals that
CCL5 signaling induces GLI2 through a PI3K-AKT-I?Ba-p65 pathway and
requires GLI2 transcriptional activity to modulate
IL-6 expression and Ig secretion in vitro and in vivo
Elsawa et al., Blood 2011
(Waldenstrom Macroglobulinemia) :
Furthermore,
CCL5 stimulated
IL-6 secretion in WM stromal cells resulting in increased IgM secretion by WM malignant cells via the JAK/STAT signaling pathway
Zhang et al., J Biol Chem 2013
:
In vitro,
IL-6 deficiency or Signal Transducer and Activator of Transcription 3 ( STAT3 ) knockdown in activated macrophage
attenuated the expression of CCL2, CCL3, but not
CCL5 , which resulted in less macrophage migration