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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CCL5 — IL6

Text-mined interactions from Literome

Nanki et al., J Immunol 2001 (Arthritis, Rheumatoid) : In this study we show that CCL2/monocyte chemotactic protein-1, CCL5/RANTES , and CXCL12/stromal cell derived factor-1 enhanced IL-6 and IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Kim et al., J Neurochem 2004 : Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta
Punturieri et al., J Immunol 2006 : Synthetic OMP elicited strong release of IL-6 , the principal inducer of airway mucin genes, and induced CCL5 and CXCL10 from murine AMphi only when IFN-beta was also present
Tang et al., Arthritis Rheum 2010 (Osteoarthritis) : This study was undertaken to investigate the intracellular signaling pathways involved in CCL5 induced interleukin-6 (IL-6) production in human synovial fibroblasts ... CCL5 mediated IL-6 expression was assessed by quantitative polymerase chain reaction and enzyme linked immunosorbent assay ... Stimulation of OASFs with CCL5 induced concentration- and time dependent increases in IL-6 production ... CCL5 mediated IL-6 production was attenuated by CCR5 monoclonal antibody, CCR5 inhibitor ( Met-RANTES ), and CCR5 siRNA ... The present results suggest that the interaction between CCL5 and CCR5 increases IL-6 production in human synovial fibroblasts via the PKCd/c-Src/c-Jun and AP-1 signaling pathways
Elsawa et al., J Biol Chem 2011 (Neoplasms) : CCL5 increases IL-6 expression and secretion in bone marrow stromal cells ... Analysis of the mechanism reveals that CCL5 signaling induces GLI2 through a PI3K-AKT-I?Ba-p65 pathway and requires GLI2 transcriptional activity to modulate IL-6 expression and Ig secretion in vitro and in vivo
Elsawa et al., Blood 2011 (Waldenstrom Macroglobulinemia) : Furthermore, CCL5 stimulated IL-6 secretion in WM stromal cells resulting in increased IgM secretion by WM malignant cells via the JAK/STAT signaling pathway
Zhang et al., J Biol Chem 2013 : In vitro, IL-6 deficiency or Signal Transducer and Activator of Transcription 3 ( STAT3 ) knockdown in activated macrophage attenuated the expression of CCL2, CCL3, but not CCL5 , which resulted in less macrophage migration