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ECE1 — EPHB2
Text-mined interactions from Literome
Eto et al., Circ Res 2001
:
On the other hand, inhibition of
ERK1 and ERK2 activation by PD98059 ( 50 micromol/L )
prevented the upregulation of ECE-1 expression by thrombin as well as the increase in
ECE activity and ET-1 accumulation in the medium
Khimji et al., Am J Pathol 2008
(Liver Diseases) :
In addition, inhibition of
ERK activation in stellate cells from BDL injured liver
led to a decrease in expression of
endothelin converting enzyme-1 , a critical regulator of endothelin-1
Cottrell et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
ECE-1 inhibition caused endosomal retention of the SP neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas
ECE-1 overexpression
attenuated ERK2 activation