Gene interactions and pathways from curated databases and text-mining

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IL1RN — IL2

Text-mined interactions from Literome

Mühlberg et al., J Clin Endocrinol Metab 2000 (Graves Disease) : Recent data have indicated that orbital fibroblasts ( OF ) can be stimulated to produce marked quantities of interleukin-1 receptor antagonist ( IL-1RA ), a powerful inhibitor of the proinflammatory activities of interleukin-1 in the orbital tissues in Graves ' ophthalmopathy ( GO )
Verheyen et al., Immunol Invest 2001 : IL-1 and IL-1 receptor antagonist (IL-1Ra) were up-regulated by IL-2 , this was achieved independently of IL-12 or CD40/CD40L interaction
Kovár et al., Parasitol Res 2002 : ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin (IL)-1alpha, IL-1beta, IL-1Ra , IL-6, and IL-12p40 cytokines, whereas production of IL-2 , IL-5, IL-10, and IL-13 was decreased
Conti et al., Int J Immunopharmacol 1992 (Leukemia, T-Cell) : The enhancing effect of IL-1ra on IL-2 activity was similar to that provoked by IL-1 beta
Cominelli et al., Gastroenterology 1992 (Colitis) : Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis
Burger et al., J Clin Invest 1995 : The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor
Du Bois et al., J Clin Oncol 1997 (Carcinoma, Renal Cell...) : IL-2 induced TNF bioactivity, neutrophil chemotactic defect, and serum IL-6, IL-8, and IL-1 receptor antagonist (IL-1RA) induction were suppressed by rhuTNFR : Fc