UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PDGFB

GRB2 — PDGFB

Pathways - manually collected, often from reviews:

NCI Pathway Database PDGFR-beta signaling pathway: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: None → PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) (modification, collaborate)
Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) (modification, collaborate)
Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) → None (modification, activates) Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: GRB2/DOCK4/Dynamin 2 complex (GRB2-DOCK4-DNM2) → PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) (modification, collaborate)
Kawada et al., Mol Cell Biol 2009
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: GRB2/DOCK4/Dynamin 2 complex (GRB2-DOCK4-DNM2) → PDGF-BB/PDGFRB (dimer)/GRB2/DOCK4/Dynamin 2 complex (PDGFRB-GRB2-DOCK4-DNM2-PDGFB) (modification, collaborate)
Kawada et al., Mol Cell Biol 2009
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/DOCK4/Dynamin 2 complex (PDGFRB-GRB2-DOCK4-DNM2-PDGFB) (modification, collaborate)
Kawada et al., Mol Cell Biol 2009
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database SHP2 signaling: None → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database SHP2 signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) → None (modification, activates) Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
Evidence: mutant phenotype
NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database SHP2 signaling: PDGF-BB/PDGFRB (dimer)/SHP2 complex (PDGFRB-PTPN11-PDGFB) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database SHP2 signaling: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/GRB2/SOS1/SHP2 complex (PDGFRB-GRB2-SOS1-PTPN11-PDGFB) (modification, collaborate)
Li et al., Mol Cell Biol 1994
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/p52 SHC/GRB2/SOS1 complex (PDGFRB-SHC1-GRB2-SOS1-PDGFB) → PDGF-BB/PDGFRB (dimer)/p52 SHC complex (PDGFRB-SHC1-PDGFB) (modification, collaborate)
Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: GRB2/SOS1 complex (GRB2-SOS1) → PDGF-BB/PDGFRB (dimer)/p52 SHC complex (PDGFRB-SHC1-PDGFB) (modification, collaborate)
Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
Evidence: physical interaction
Reactome Reaction: GRB2 → PDGFB (reaction) Arvidsson et al., Mol Cell Biol 1994, Satoh et al., Mol Cell Biol 1993, Heldin et al., Biochim Biophys Acta 1998
Reactome Reaction: GRB2 → PDGFB (indirect_complex) Arvidsson et al., Mol Cell Biol 1994, Satoh et al., Mol Cell Biol 1993, Heldin et al., Biochim Biophys Acta 1998